Sandbox Reserved 382: Difference between revisions
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<Structure load='3EQM' size='400' frame='true' align='right' caption='Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione (PDB entry [http://www.pdb.org/pdb/explore/explore.do?structureId=3EQM])' scene='Insert optional scene name here' /> | <Structure load='3EQM' size='400' frame='true' align='right' caption='Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione (PDB entry [http://www.pdb.org/pdb/explore/explore.do?structureId=3EQM])' scene='Insert optional scene name here' /> | ||
== Introduction == | == Introduction == | ||
Aromatase is an enzyme that aids in the biosynthesis of estrogens | Aromatase belongs to the cytochrome p450 family. During aromatization reactions, Aromatase forms an electron-transfer complex with its partner, NADPH-cytochrome p450 reductase. Aromatase is an enzyme that aids in the biosynthesis of estrogens. The aromatase enzyme can be found in many tissues in the body such as the brain, placenta, adipose tissue, blood vessels, gonads, endometrium, skin, and bone. | ||
== Function == | == Function == | ||
This enzyme helps produce this female sex hromone that helps to fuel the growth of hormone receptor-positive breast cancer. | |||
== Aromatase Inhibitors == | == Aromatase Inhibitors == | ||
Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. | Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. | ||
