ToxT: Difference between revisions

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</ref> The preferred state of ToxT varies between promoters, but binding to the ctx promoter to generate cholera toxin appears to be possible only in the dimer form.<ref name="virstatin">PMID:17283330</ref>ToxT binds to thirteen base pair sequences (can be single, direct, or inverted repeats) called toxboxes in order to activate their respective promoters.[http://www.sigwiki.info/wiki/Signature:ToxBox]

</StructureSection>

==Further Study==

Conclusive results about what activates ToxT itself has not yet been found. The varying activity of ToxT dependent on the presence of cis-palmitoleate or other unsaturated fatty acids represents a detailed method of effective pathogenicity in humans, but may not be a reasonable target for drug treatment. By restricting transcription (and thus translation and protein production) of virulence genes until the bacterium is determined to be in a favorable location for infection, Vibrio cholerae avoids wasting energy producing virulence factors that will just be cleared by the intestine. This is a specific mechanism to ensure that the bacterium also injects CT and TCP where they will do the most damage, resulting in an infection. <ref>{{cite web|first=Kenneth |last=Todar |url=http://www.textbookofbacteriology.net/cholera.html |title=''Vibrio cholerae'' and Asiatic Cholera |publisher=Todar's Online Textbook of Bacteriology |date= |accessdate=2011-11-29}}</ref>

==References==

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@@ Line 17: / Line 17: @@
 </ref> The preferred state of ToxT varies between promoters, but binding to the <i>ctx</i> promoter to generate cholera toxin appears to be possible only in the dimer form.<ref name="virstatin">PMID:17283330</ref>ToxT binds to thirteen base pair sequences (can be single, direct, or inverted repeats) called toxboxes in order to activate their respective promoters.[http://www.sigwiki.info/wiki/Signature:ToxBox]
 </StructureSection>
+==Further Study==
+Conclusive results about what activates ToxT itself has not yet been found. The varying activity of ToxT dependent on the presence of <i>cis</i>-palmitoleate or other unsaturated fatty acids represents a detailed method of effective pathogenicity in humans, but may not be a reasonable target for drug treatment. By restricting transcription (and thus translation and protein production) of virulence genes until the bacterium is determined to be in a favorable location for infection, <i>Vibrio cholerae</i> avoids wasting energy producing virulence factors that will just be cleared by the intestine. This is a specific mechanism to ensure that the bacterium also injects CT and TCP where they will do the most damage, resulting in an infection. <ref>{{cite web|first=Kenneth |last=Todar |url=http://www.textbookofbacteriology.net/cholera.html |title=''Vibrio cholerae'' and Asiatic Cholera |publisher=Todar's Online Textbook of Bacteriology |date= |accessdate=2011-11-29}}</ref>
 ==References==
 <references/>