User:Andrea Danielle Merr: Difference between revisions
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== Tamoxifen == | |||
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Recent studies have shown that those with high estrogen levels, coupled with an already high risk of developing breast cancer are at a higher risk of the disease occurring. Estrogen is necessary in many areas of the body. Estrogen gives cells permission to grow, including cancer cells. Estrogen is regulated through an activated estrogen receptor transcription factor. These transcription factors in the higher risk patients can activate oncogenes that accelerate cancer cell growth. A new hypothesis suggests that a new way to prevent and treat breast cancer is to change the way estrogen binds to the receptor. Normally, estrogen binds to the estrogen receptor, allowing DNA to bind to it to it to initiate transcription of reproductive cycle-related genes. .<ref>PMID: 15610857 </ref> | |||
Revision as of 01:55, 30 November 2011
Tamoxifen
Recent studies have shown that those with high estrogen levels, coupled with an already high risk of developing breast cancer are at a higher risk of the disease occurring. Estrogen is necessary in many areas of the body. Estrogen gives cells permission to grow, including cancer cells. Estrogen is regulated through an activated estrogen receptor transcription factor. These transcription factors in the higher risk patients can activate oncogenes that accelerate cancer cell growth. A new hypothesis suggests that a new way to prevent and treat breast cancer is to change the way estrogen binds to the receptor. Normally, estrogen binds to the estrogen receptor, allowing DNA to bind to it to it to initiate transcription of reproductive cycle-related genes. .[1]
- ↑ Serganov A, Yuan YR, Pikovskaya O, Polonskaia A, Malinina L, Phan AT, Hobartner C, Micura R, Breaker RR, Patel DJ. Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol. 2004 Dec;11(12):1729-41. PMID:15610857 doi:S1074-5521(04)00343-6
