Cowpea Chlorotic Mottle Virus: Difference between revisions
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<ref name=Arisaka, Fumio. Virus Capsid Model; Tokyo Institute of Technology> | <ref name=Arisaka, Fumio. Virus Capsid Model; Tokyo Institute of Technology</ref> | ||
Prior to the characterization of CCMV's structure, no RNA viruses (in plants and insects) were found to rigorously observe this model. Their prediction necessitated that the pentamer and hexamer subunits would from a single chemical structure (realized in CCMV due to its identical A,B, and C gene products). However, the "molecular switch" that determines whether a pentamer or a hexamer would form, was left undefined. | Prior to the characterization of CCMV's structure, no RNA viruses (in plants and insects) were found to rigorously observe this model. Their prediction necessitated that the pentamer and hexamer subunits would from a single chemical structure (realized in CCMV due to its identical A,B, and C gene products). However, the "molecular switch" that determines whether a pentamer or a hexamer would form, was left undefined. | ||
It appears that after dimer formation, hexamers predominate in solution. The authors propose that the hexamers then form nucleation sites for particle formation. The basis for the additional hexamer stability comes from the relative number of interactions between molecules. | It appears that after dimer formation, hexamers predominate in solution. The authors propose that the hexamers then form nucleation sites for particle formation. The basis for the additional hexamer stability comes from the relative number of interactions between molecules. | ||
