Sandbox Reserved 382: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
|||
| Line 10: | Line 10: | ||
== Structure== | == Structure== | ||
Due to the membrane-bound nature of mammalian cytochromes P450 (CYP), the structural characterization is extremely difficult. Aromatase is a monomeric enzyme composed of a heme-prosthetic group and a single polypeptide chain consisting of 503 amino-acid residues. <ref> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. "X-ray Structure of Human Aromatase Reveals An Androgen Specific Active Site". [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/] </ref> One important feature of CYPs is the iron-containing porphyrin group at the enzyme active site. <ref> PMID: 16395678 </ref> Aromatase is anchored to the endoplasmic reticulum by the amino terminal transmembrane domain. | Due to the membrane-bound nature of mammalian cytochromes P450 (CYP), the structural characterization is extremely difficult. Aromatase is a monomeric enzyme composed of a heme-prosthetic group and a single polypeptide chain consisting of 503 amino-acid residues. <ref> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. "X-ray Structure of Human Aromatase Reveals An Androgen Specific Active Site". [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/] </ref> One important feature of CYPs is the iron-containing porphyrin group at the enzyme active site. <ref> PMID: 16395678 </ref> Aromatase is anchored to the endoplasmic reticulum by the amino terminal transmembrane domain. | ||
[[Image:Aromatase_Structure.jpg | [[Image:Aromatase_Structure.jpg]] | ||
== Aromatase Inhibitors == | == Aromatase Inhibitors == | ||
