Sandbox Reserved 384: Difference between revisions
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*[[User:LoganBrushart/Sandbox reserved 384]] | *[[User:LoganBrushart/Sandbox reserved 384]] | ||
<Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /> | <Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='<scene name='Sandbox_Reserved_384/Standard_scene/1'>TextToBeDisplayed</scene>' /> | ||
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{{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }} | {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }} | ||
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===Molecular Function=== | ===Molecular Function=== | ||
The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though<scene name='Sandbox_Reserved_384/Hydrophobics/1'>hydrophobic interactions</scene> and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<ref>PMID:11334402</ref> | The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though <scene name='Sandbox_Reserved_384/Hydrophobics/1'>hydrophobic interactions</scene> and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<ref>PMID:11334402</ref> | ||
===Ongoing Research=== | ===Ongoing Research=== | ||
