Sandbox Reserved 381: Difference between revisions
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== OGT Features of Interest == | == OGT Features of Interest == | ||
The OGT protein possess two ligands <scene name='Sandbox_Reserved_381/So4_ligand/1'>SO<sub>4</sub></scene> and UDP. | |||
OGT is the only known member to glycosylate polypeptides and it contains a long uncharacterized intervening sequence (~120 amino acids) in the middle of the catalytic region. Studies suggest that OGT contains a phosphatidylinositol (3,4,5)-trisphosphate (PIP<sub>3</sub>)binding domain. The most unusual feature of OGT is the intervening domain between the catalytic lobes, which is only found in metazoans. This polypeptide adopts a topologically novel fold with a seven-stranded <scene name='Sandbox_Reserved_381/Ogt_structure/1'>beta sheet</scene> core stabilized by flanking alpha helices. There are two long <scene name='Sandbox_Reserved_381/Unstructured_loops/1'>unstructured loops</scene> for which electron density is missing.<ref> PMID:18288188</ref> | OGT is the only known member to glycosylate polypeptides and it contains a long uncharacterized intervening sequence (~120 amino acids) in the middle of the catalytic region. Studies suggest that OGT contains a phosphatidylinositol (3,4,5)-trisphosphate (PIP<sub>3</sub>)binding domain. The most unusual feature of OGT is the intervening domain between the catalytic lobes, which is only found in metazoans. This polypeptide adopts a topologically novel fold with a seven-stranded <scene name='Sandbox_Reserved_381/Ogt_structure/1'>beta sheet</scene> core stabilized by flanking alpha helices. There are two long <scene name='Sandbox_Reserved_381/Unstructured_loops/1'>unstructured loops</scene> for which electron density is missing.<ref> PMID:18288188</ref> | ||
