Sandbox Reserved 383: Difference between revisions

Human dopamine D3 receptor is 64% helical and 1% beta sheet. The protein is composed of 20 helices and 3 beta sheet strands. The helices are made up of 312 residues and the bate sheets are made up of 9 residues.  The entire protein consists of 481 residues.<ref>http://www.pdb.org/pdb/explore.do?structureId=3PBL</ref> Dopamine D3 receptors are greatly expressed in the Islands of Calleja, a group of neural granule cells located within the ventral striatum in the brains of most animals, which is part of the limbic system. It is also found in the nucleus accumbens, a collection of neurons and forms the main part of the ventral striatum.<ref>Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, Sedvall G (January 1998). "D3 dopamine receptor mRNA is widely expressed in the human brain". Brain Res. 779 (1–2): 58–74. doi:10.1016/S0006-8993(97)01078-0. PMID 9473588.</ref>

  [[Image:250px-Islands_of_Calleja_Rat.jpg|250px|left|thumb| Islands of Calleja of rat brain stained in blue.]]

==Ligands==