Sandbox Reserved 382: Difference between revisions
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== Function == | == Function == | ||
The primary function of Aromatase is to produce estrogens by aromatizing androgens. Aromatase is the only known enzyme in vertebrates capable of catalyzing the aromatization of a six-membered ring <ref name="structure"/>. Aromatase converts androstenedione to estrogen and testosterone to estradiol. <ref name="products" /> Aromatase is also a key enzyme in the biosynthesis of estrogens through a process called steroidogenesis. This enzyme helps produce this female sex hormone, estrogen, that helps to fuel the growth of hormone receptor-positive breast cancer. | The primary function of Aromatase is to produce estrogens by aromatizing androgens. Aromatase is the only known enzyme in vertebrates capable of catalyzing the aromatization of a six-membered ring <ref name="structure"> PMID:2826573 </ref>. Aromatase converts androstenedione to estrogen and testosterone to estradiol. <ref name="products" /> Aromatase is also a key enzyme in the biosynthesis of estrogens through a process called steroidogenesis. This enzyme helps produce this female sex hormone, estrogen, that helps to fuel the growth of hormone receptor-positive breast cancer. | ||
[[Image:Aromatase_Structure.jpg|thumb|260px|left| Ribbon diagram displaying the overall structure of human placental aromatase. <ref name="structure"/>]] | [[Image:Aromatase_Structure.jpg|thumb|260px|left| Ribbon diagram displaying the overall structure of human placental aromatase. <ref name="structure"/>]] | ||
