Anthrax Lethal Factor: Difference between revisions

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'''<scene name='Anthrax_Lethal_Factor/Domain_-3-/1'>Domain III</scene>''' (residues 303-383), contains a segment of five tandem repeats residues 282-382. This suggests that repeats 2-5 arose from a duplication of repeat 1, the second helix-turn element of domain II. ~~Whereas repeats~~ 2-5 form the four helix-turn elements of the helical bundle. This domain is required LF activity, shares the same hydrophobic surface as domain IV and its location restricts access to the active site. Also, it contributes to substrate specificity by making interactions with the substrate. <ref name=Collier>PMID: 14570563</ref><ref name=Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC>PMID: 11700563</ref>

'''<scene name='Anthrax_Lethal_Factor/Domain_-3-/1'>Domain III</scene>''' (residues 303-383), contains a segment of five tandem repeats residues 282-382. This suggests that repeats 2-5 arose from a duplication of repeat 1, which is the second helix-turn element of domain II. Repeats 2-5 form the four helix-turn elements of the helical bundle. This domain is required LF activity, shares the same hydrophobic surface as domain IV and its location restricts access to the active site. Also, it contributes to substrate specificity by making interactions with the substrate. <ref name=Collier>PMID: 14570563</ref><ref name=Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC>PMID: 11700563</ref>

Anthrax Lethal Factor: Difference between revisions

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Revision as of 21:01, 1 December 2011 view source Peter Aziz (talk \| contribs) 80 edits No edit summary ← Older edit		Revision as of 22:32, 1 December 2011 view source Peter Aziz (talk \| contribs) 80 edits No edit summary Newer edit →
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	'''<scene name='Anthrax_Lethal_Factor/Domain_-3-/1'>Domain III</scene>''' (residues 303-383), contains a segment of five tandem repeats residues 282-382. This suggests that repeats 2-5 arose from a duplication of repeat 1, the second helix-turn element of domain II. ~~Whereas repeats~~ 2-5 form the four helix-turn elements of the helical bundle. This domain is required LF activity, shares the same hydrophobic surface as domain IV and its location restricts access to the active site. Also, it contributes to substrate specificity by making interactions with the substrate. <ref name=Collier>PMID: 14570563</ref><ref name=Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC>PMID: 11700563</ref>		'''<scene name='Anthrax_Lethal_Factor/Domain_-3-/1'>Domain III</scene>''' (residues 303-383), contains a segment of five tandem repeats residues 282-382. This suggests that repeats 2-5 arose from a duplication of repeat 1, which is the second helix-turn element of domain II. Repeats 2-5 form the four helix-turn elements of the helical bundle. This domain is required LF activity, shares the same hydrophobic surface as domain IV and its location restricts access to the active site. Also, it contributes to substrate specificity by making interactions with the substrate. <ref name=Collier>PMID: 14570563</ref><ref name=Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC>PMID: 11700563</ref>