Atragin: Difference between revisions

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==Structure==

<scene name='Atragin/All_domains/1'>Atragin</scene> is a 63x52x67 Å protein that contains a Metalloprotease domain, Disintegrin-like domain, and a cysteine-rich domain<ref name=Guan>PMID: 19932752</ref>. The overall architecture of the protein gives a <scene name='Atragin/C-like_structre/1'>C-shaped</scene> structure that is similar to other P-III SVMPs such as VAP1 <ref name=Takeda>PMID: 16688218</ref> in that the recognition site of the C domain faces the M domain’s catalytic cleft in a linear orientation, which means the target recognized by the C domain could be the same as the substrate catalyzed by M domain. This is a contrast to other P-III SVMPs which can have an I-shaped structure that contains a non-linear orientation between the C and M domains, in which the target recognized by the C domain can be different than the catalyzed substrate molecule <ref name=Guan>PMID: 19932752</ref>.

<scene name='Atragin/All_domains/1'>Atragin</scene> is a 63x52x67 Å protein that contains a Metalloprotease domain, Disintegrin-like domain, and a cysteine-rich domain<ref name=Guan>PMID: 19932752</ref>. The overall architecture of the protein gives a <scene name='Atragin/C-like_structre/1'>C-shaped</scene> structure that is similar to other P-III SVMPs such as VAP1 <ref name=Takeda>PMID: 16688218</ref> in that the recognition site of the C domain faces the M domain’s catalytic cleft in a linear orientation, which means the target recognized by the C domain could be the same as the substrate catalyzed by M domain. This is a contrast to other P-III SVMPs, such as the K-like protein shown below, which can have an I-shaped structure that contains a non-linear orientation between the C and M domains, in which the target recognized by the C domain can be different than the catalyzed substrate molecule <ref name=Guan>PMID: 19932752</ref>.

[[Image:C_vs_I.jpg]] <ref name=Guan>PMID: 19932752</ref>

'''Metalloprotease Domain ''

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 ==Structure==
-<scene name='Atragin/All_domains/1'>Atragin</scene> is a 63x52x67 Å protein that contains a Metalloprotease domain, Disintegrin-like domain, and a cysteine-rich domain<ref name=Guan>PMID: 19932752</ref>. The overall architecture of the protein gives a <scene name='Atragin/C-like_structre/1'>C-shaped</scene> structure that is similar to other P-III SVMPs such as VAP1 <ref name=Takeda>PMID: 16688218</ref> in that the recognition site of the C domain faces the M domain’s catalytic cleft in a linear orientation, which means the target recognized by the C domain could be the same as the substrate catalyzed by M domain. This is a contrast to other P-III SVMPs which can have an I-shaped structure that contains a non-linear orientation between the C and M domains, in which the target recognized by the C domain can be different than the catalyzed substrate molecule <ref name=Guan>PMID: 19932752</ref>.
+<scene name='Atragin/All_domains/1'>Atragin</scene> is a 63x52x67 Å protein that contains a Metalloprotease domain, Disintegrin-like domain, and a cysteine-rich domain<ref name=Guan>PMID: 19932752</ref>. The overall architecture of the protein gives a <scene name='Atragin/C-like_structre/1'>C-shaped</scene> structure that is similar to other P-III SVMPs such as VAP1 <ref name=Takeda>PMID: 16688218</ref> in that the recognition site of the C domain faces the M domain’s catalytic cleft in a linear orientation, which means the target recognized by the C domain could be the same as the substrate catalyzed by M domain. This is a contrast to other P-III SVMPs, such as the K-like protein shown below, which can have an I-shaped structure that contains a non-linear orientation between the C and M domains, in which the target recognized by the C domain can be different than the catalyzed substrate molecule <ref name=Guan>PMID: 19932752</ref>.
+[[Image:C_vs_I.jpg]] <ref name=Guan>PMID: 19932752</ref>
 '''Metalloprotease Domain ''