Sandbox Reserved 387: Difference between revisions

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== Mediator==

The Mediator, found in the yeast S. cerevisiae, connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription <ref>PMID: 21725323 </ref> (Pol II). Also, mediator is currently being studied because of its ability and role to regulate gene expression <ref>PMID: 20299225 </ref>. Mediator is in the form of three main modules, which are the tail, arm, and head. The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of the mediator is split into three domains that go through significant conformational changes, and it interracts with the Rpb7 and Rpb4 subunits of Pol II and TATA binding protein subunit of transcription factor TFIID. <ref>PMID: 21725323 </ref>

The Mediator, found in the yeast S. cerevisiae, connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription <ref>PMID: 21725323 </ref> (Pol II). Also, mediator is currently being studied because of its ability and role to regulate gene expression <ref>PMID: 20299225 </ref>. Mediator is in the form of three main modules, which are the tail, arm, and head. The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of the mediator is split into three domains that go through significant conformational changes, and it interracts with the Rpb7 and Rpb4 subunits of Pol II and TATA binding protein subunit of transcription factor TFIID. <ref>PMID: 21725323 </ref> These three domains are the neck, fixed jaw, and movable jaw.

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== Primary Structure ==

The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of mediator from S.cerevisiae is made of seven subunits which are Med22(Srb6), Med20(Srb2), Med18(Srb5), Med17(Srb4), Med11, Med6, and Med8 <ref>PMID: 21725323 </ref>. Of these subunits, Med11, Med17(Srb4), and Med22(Srb6) make the mini-head of the head module. The subunits of the core-head plus the subunits of the mini-head are what make up full head. structure.

Sandbox Reserved 387: Difference between revisions

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@@ Line 8: / Line 8: @@
 == Mediator==
-The Mediator, found in the yeast S. cerevisiae, connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription <ref>PMID: 21725323 </ref> (Pol II). Also, mediator is currently being studied because of its ability and role to regulate gene expression <ref>PMID: 20299225 </ref>. Mediator is in the form of three main modules, which are the tail, arm, and head. The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of the mediator is split into three domains that go through significant conformational changes, and it interracts with the Rpb7 and Rpb4 subunits of Pol II and TATA binding protein subunit of transcription factor TFIID. <ref>PMID: 21725323 </ref>
+The Mediator, found in the yeast S. cerevisiae, connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription <ref>PMID: 21725323 </ref> (Pol II). Also, mediator is currently being studied because of its ability and role to regulate gene expression <ref>PMID: 20299225 </ref>. Mediator is in the form of three main modules, which are the tail, arm, and head. The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of the mediator is split into three domains that go through significant conformational changes, and it interracts with the Rpb7 and Rpb4 subunits of Pol II and TATA binding protein subunit of transcription factor TFIID. <ref>PMID: 21725323 </ref> These three domains are the neck, fixed jaw, and movable jaw.
@@ Line 14: / Line 14: @@
 == Primary Structure ==
 The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of mediator from S.cerevisiae is made of seven subunits which are Med22(Srb6), Med20(Srb2), Med18(Srb5), Med17(Srb4), Med11, Med6, and Med8 <ref>PMID: 21725323 </ref>. Of these subunits, Med11, Med17(Srb4), and Med22(Srb6) make the mini-head of the head module. The subunits of the core-head plus the subunits of the mini-head are what make up full head. structure.