Sandbox Reserved 382: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 10: | Line 10: | ||
== Function == | == Function == | ||
The primary function of aromatase is to produce estrogens by aromatizing androgens. Aromatase is the only known enzyme in vertebrates capable of catalyzing the aromatization of a six-membered ring<ref name="structure"> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. " X-ray Structure of Human Aromatase Reveals An Androgen-Specific Active Site" ''Journal of Steroid Biochemistry and Molecular Biology''. [Online] '''2010''',Vol. 118, Issue 4-5, p197-202. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/]</ref>. Aromatase converts androstenedione to estrogen and testosterone to estradiol.<ref name="products" /> Aromatase is also a key enzyme in the biosynthesis of estrogens through a process called steroidogenesis. This enzyme helps produce the female sex hormone, estrogen, that helps to fuel the growth of hormone receptor-positive breast cancer. | The primary function of aromatase is to produce estrogens by aromatizing androgens. Aromatase is the only known enzyme in vertebrates capable of catalyzing the aromatization of a six-membered ring<ref name="structure"> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. " X-ray Structure of Human Aromatase Reveals An Androgen-Specific Active Site" ''Journal of Steroid Biochemistry and Molecular Biology''. [Online] '''2010''',Vol. 118, Issue 4-5, p197-202. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/]</ref>. Aromatase converts androstenedione to estrogen and testosterone to estradiol.<ref name="products" /> Aromatase is also a key enzyme in the biosynthesis of estrogens through a process called steroidogenesis. This enzyme helps produce the female sex hormone, estrogen, that helps to fuel the growth of hormone receptor-positive breast cancer. | ||
There are many environmental factors that affect the activity of the aromatase enzyme and disrupt its function. Factors that increase the activity of the enzyme include age, obesity, gonadotropins, insulin | There are many environmental factors that affect the activity of the aromatase enzyme and disrupt its function. Factors that increase the activity of the enzyme include age, obesity, gonadotropins, insulin, alcohol and smoking.<ref name="products"> "Aromatase Products" [http://www.novusbio.com/aromatase#13225047480835&ga_enabled%3B0] </ref> | ||
[[Image:Aromatase_Structure.jpg|thumb|260px|left| Ribbon diagram displaying the overall structure of human placental aromatase. <ref name="structure"/>]] | [[Image:Aromatase_Structure.jpg|thumb|260px|left| Ribbon diagram displaying the overall structure of human placental aromatase. <ref name="structure"/>]] | ||
