Sandbox 300: Difference between revisions

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Staphylococcal protein A is originally a component of the cell wall in over 90% of ''Staphylococcus aureus'' strains.<ref>Peterson, P. K., Verhoef, J., Sabath, L. D., & Quie, P. G. (1977). Effect of protein A on staphylococcal opsonization. Infection and immunity, 15(3), 760-4</ref>

Staphylococcal protein A is originally a component of the cell wall in over 90% of ''Staphylococcus aureus'' strains<ref>Peterson, P. K., Verhoef, J., Sabath, L. D., & Quie, P. G. (1977). Effect of protein A on staphylococcal opsonization. Infection and immunity, 15(3), 760-4</ref>.

This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall.

This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall<ref>Hjelm, H., Sjödahl, J., & Sjöquist, J. (1975). Immunologically active and structurally similar fragments of protein A from Staphylococcus aureus. European journal of biochemistry / FEBS, 57(2), 395-403</ref>.

Nowadays the protein is often used for biochemical analysis due to its structural and biochemical properties.

The expression of the chromosomal spa gene, which encodes the protein A, is regulated by the ''agr'' system and Rot. The level of expression is up-regulated by Rot and down-regulated by ''agr''.

Sandbox 300: Difference between revisions

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 <Structure load='PDBREF' size='300' frame='true' align='right' caption='Staphylococcal protein A' scene='Insert optional scene name here' />
-Staphylococcal protein A is originally a component of the cell wall in over 90% of ''Staphylococcus aureus'' strains.<ref>Peterson, P. K., Verhoef, J., Sabath, L. D., & Quie, P. G. (1977). Effect of protein A on staphylococcal opsonization. Infection and immunity, 15(3), 760-4</ref>
+Staphylococcal protein A is originally a component of the cell wall in over 90% of ''Staphylococcus aureus'' strains<ref>Peterson, P. K., Verhoef, J., Sabath, L. D., & Quie, P. G. (1977). Effect of protein A on staphylococcal opsonization. Infection and immunity, 15(3), 760-4</ref>.
-This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall.
+This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall<ref>Hjelm, H., Sjödahl, J., & Sjöquist, J. (1975). Immunologically active and structurally similar fragments of protein A from Staphylococcus aureus. European journal of biochemistry / FEBS, 57(2), 395-403</ref>.
 Nowadays the protein is often used for biochemical analysis due to its structural and biochemical properties.
 The expression of the chromosomal spa gene, which encodes the protein A, is regulated by the ''agr'' system and Rot. The level of expression is up-regulated by Rot and down-regulated by ''agr''.