Sandbox 300: Difference between revisions
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This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall<ref>Hjelm, H., Sjödahl, J., & Sjöquist, J. (1975). Immunologically active and structurally similar fragments of protein A from Staphylococcus aureus. European journal of biochemistry / FEBS, 57(2), 395-403</ref>. | This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall<ref>Hjelm, H., Sjödahl, J., & Sjöquist, J. (1975). Immunologically active and structurally similar fragments of protein A from Staphylococcus aureus. European journal of biochemistry / FEBS, 57(2), 395-403</ref>. | ||
Nowadays the protein is often used for biochemical analysis due to its structural and biochemical properties. | Nowadays the protein is often used for biochemical analysis due to its structural and biochemical properties. | ||
The expression of the chromosomal spa gene, which encodes the protein A, is regulated by the ''agr'' system and Rot. The level of expression is up-regulated by Rot and down-regulated by ''agr''. | The expression of the chromosomal ''spa'' gene, which encodes the protein A, is regulated by the ''agr'' system and Rot. The level of expression is up-regulated by Rot and down-regulated by ''agr''. | ||
Furthermore protein A serves as a virulence factor to ''Staphylococcus aureus'' . It is essential for the colonization and infections mediated by this kind of bacteria<ref>Bronner, S., Monteil, H., & Prévost, G. (2004). Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS microbiology reviews, 28(2), 183-200</ref>. | Furthermore protein A serves as a virulence factor to ''Staphylococcus aureus'' . It is essential for the colonization and infections mediated by this kind of bacteria<ref>Bronner, S., Monteil, H., & Prévost, G. (2004). Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS microbiology reviews, 28(2), 183-200</ref>. | ||
