Sandbox 27: Difference between revisions
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== Structure of the TSH Receptor == | == Structure of the TSH Receptor == | ||
[[Image:JCI0526031.f1.jpg | thumb | right | Different domains of TSHR ]] | |||
This receptor is evolutionary classified as rhodopsin-like receptors of family A. It is consisted of five different domains: | This receptor is evolutionary classified as rhodopsin-like receptors of family A. It is consisted of five different domains: | ||
* '''An extracellular domain or ectodomain''': it consists of ten leucine-rich repeats, so also called '''leucine rich domain or LRD, or LRRs'''. This ectodomain forms a concave surface (also with some contribution from the CD), it is responsible for the high affinity and selective binding of the corresponding hormones. | * '''An extracellular domain or ectodomain''': it consists of ten leucine-rich repeats, so also called '''leucine rich domain or LRD, or LRRs'''. This ectodomain forms a concave surface (also with some contribution from the CD), it is responsible for the high affinity and selective binding of the corresponding hormones. | ||
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Here is a scheme of the THS bound to its receptor TSRH: | Here is a scheme of the THS bound to its receptor TSRH: | ||
