Sandbox 27: Difference between revisions
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[[Image:JCI0526031.f1.jpg | thumb | right | Different domains of TSHR ]] | [[Image:JCI0526031.f1.jpg | thumb | right | Different domains of TSHR ]] | ||
This receptor is evolutionary classified as rhodopsin-like receptors of family A. It is consisted of five different domains (as represented on the opposite scheme) | This receptor is evolutionary classified as rhodopsin-like receptors of family A. It is consisted of five different domains (as represented on the opposite scheme) | ||
* '''An extracellular domain or ectodomain''': it consists of ten leucine-rich repeats, so also called '''leucine rich domain or LRD, or LRRs'''. This ectodomain | * '''An extracellular domain or ectodomain''': it consists of ten leucine-rich repeats, so also called '''leucine rich domain or LRD, or LRRs'''. This ectodomain has a shape of slightly curved helical tube(also with some contribution from the CD), it is responsible for the high affinity and selective binding of the corresponding hormones. | ||
* '''A N-Terminal tail''' : it contains four half-cystines linked by disulfide bonds to the first of ten repeats of the LRD. | * '''A N-Terminal tail''' : it contains four half-cystines linked by disulfide bonds to the first of ten repeats of the LRD. | ||
