Sandbox 213: Difference between revisions
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<Structure load='3CLN' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='3CLN' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
Calmodulin (CaM) is an important protein that intervenes in a wide range of activities. Indeed, it is a small (16.7 kDa=148 aa) and highly conserved protein that is necessary in all eukaryotic cells because it represents an essential calcium sensor with troponin C its isoform. Calmodulin contains four Ca2+ binding sites and the binding of calcium induces a conformational change in calmodulin that can cause the activation of key enzymes such as kinases or phosphatases proteins (especially phosphorylase kinases) which are not necessarily themselves Ca2+-sensitive and allows a large diversity of cellular response. | Calmodulin (CaM) is an important protein that intervenes in a wide range of activities. | ||
Indeed, it is a small (16.7 kDa=148 aa) and highly conserved protein that is necessary in all eukaryotic cells because it represents an essential calcium sensor with troponin C its isoform. | |||
Calmodulin contains four Ca2+ binding sites and the binding of calcium induces a conformational change in calmodulin that can cause the activation of key enzymes such as kinases or phosphatases proteins (especially phosphorylase kinases) which are not necessarily themselves Ca2+-sensitive and allows a large diversity of cellular response. | |||
==Calmodulin structure== | ==Calmodulin structure== | ||
