Sandbox 210

CDK5-p25 complex

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1h4l' size='350' frame='false' scene=
1h4l, resolution 2.65Å (default scene)
Related:	1lfr
Structural annotation: Resources: CATH : 1H4La02, 1H4La01, 1H4Lb01, 1H4Lb02, 1H4Ld00, 1H4Le00 InterPro : Ipr008271, Ipr011009, Ipr000719, Ipr002290, Ipr013763, Ipr004944, Ipr011028 Pfam : PF00069, PF03261 SCOP : d1h4la_, d1h4lb_, d1h4ld_, d1h4le_ UniProt : Q00535, Q15078
Functional annotation: Cellular component: nucleus dendrite growth cone cell soma neuromuscular junction lamellipodium cell projection membrane cytosol axon cytoplasm filopodium dendritic spine cyclin-dependent protein kinase 5 activator complex contractile fiber Biological process: neuron differentiation cell migration embryonic development axonogenesis neurite development cell division cell proliferation protein amino acid phosphorylation regulation of cell migration positive regulation of neuron apoptosis cell cycle cell-matrix adhesion neuron migration ionotropic glutamate receptor signaling pathway brain development neuron adhesion regulation of cyclin-dependent protein kinase activity axon guidance regulation of neuron differentiation axonal fasciculation acetylcholine receptor signaling, muscarinic pathway Molecular function: ErbB-3 class receptor binding cyclin-dependent protein kinase activity ATP binding nucleotide binding transferase activity protein binding ErbB-2 class receptor binding protein kinase activity acetylcholine receptor activator activity kinase activity tau-protein kinase activity protein serine/threonine kinase activity cadherin binding calcium ion binding cyclin-dependent protein kinase 5 activator activity protein serine/threonine kinase activator activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Cdk5 means Cyclin-dependent kinase 5. This protein could form a complex with p25, an other protein.

Structure

Sequence similarities

The chains A and B of the Cdk5-p25 complex share homologuous sequences with the cell division protein kinase 5 and the chains D and E with the cyclin-dependent kinase 5 activator.