Virus protease: Difference between revisions

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[[Image:1odw.png|left|200px|thumb|Crystal Structure of HIV-1 protease [[1odw]]]]
[[Image:1odw.png|left|200px|thumb|Crystal Structure of HIV-1 protease [[1odw]]]]
{{STRUCTURE_1odw|  PDB=1odw  | SIZE=300| SCENE=Virus_protease/Cv/1 |right|CAPTION=HIV-1 protease complex with tert-butylcarbonate [[1odw]] }}
{{STRUCTURE_1odw|  PDB=1odw  | SIZE=400| SCENE=Virus_protease/Cv/1 |right|CAPTION=HIV-1 protease complex with tert-butylcarbonate [[1odw]] }}


'''Virus proteases''' include HIV protease, XMRV protease, retropepsin.
'''Virus proteases''' include HIV protease, XMRV protease, retropepsin.
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== 3D Structures of Virus proteases ==
== 3D Structures of Virus proteases ==


''Update June 2011''
''Update December 2011''


===HIV-1===
===HIV-1===


[[3ixo]] - HIV1-PR subtype A<br />
[[3ixo]] - HIV1-PR subtype A<br />
[[1odx]], [[ 2hb2]], [[ 2hb4]], [[ 2pc0]] - HIV1-PR (mutant) <br />
[[1odx]], [[ 2hb2]], [[ 2hb4]], [[ 2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]] - HIV1-PR (mutant) <br />
[[1rpi]], [[ 1rq9]], [[ 1tw7]] - HIV1-PR (drug-resistant mutant) <br />
[[1rpi]], [[ 1rq9]], [[ 1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]] - HIV1-PR (drug-resistant mutant) <br />
[[1odw]], [[ 3kf1]] - HIV1-PR
[[1odw]], [[ 3kf1]], [[3hvp]], [[3phv]] - HIV1-PR<br />
[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer


===HIV-1 complexes===
===HIV-1 complexes===


[[1hsg]], [[ 1hsh]], [[ 1hsi]], [[ 3oxc]], [[ 3ekv]], [[ 3ekx]], [[ 3eky]], [[ 3el1]], [[ 1ohr]] - HIV1-PR + antiviral drug<br />
[[1hsg]], [[ 1hsh]], [[ 1hsi]], [[ 3oxc]], [[ 3ekv]], [[ 3ekx]], [[ 3eky]], [[ 3el1]], [[ 1ohr]] - HIV1-PR + antiviral drug<br />
[[1aid]], [[ 1qbr]], [[ 1qbs]], [[ 1qbt]], [[ 1qbu]], [[ 3mxe]], [[ 3m9f ]], [[ 3kf0]], [[ 3kf1]], [[ 3kfn]], [[ 3kfp]], [[ 3kfr]], [[ 3kfs]], [[ 2wkz]], [[ 2wl0]], [[ 3gga]], [[ 3ggv]], [[ 3ggx]], [[ 2uxz]], [[ 2uy0]], [[ 1zp8]], [[ 1xl2]], [[ 1xl5]], [[ 1zpa]], [[ 1yt9]], [[ 2a4f ]], [[ 1upj]], [[ 2upj]], [[ 7upj]], [[ 1hxb]], [[ 1hih]], [[ 1hvr]], [[ 1hef]], [[ 1heg]], [[ 4phv]], [[ 1w5w]], [[ 1w5x]], [[ 1w5v]], [[ 1w5y]], [[ 1t7k]], [[ 1npa]], [[ 1npv]], [[ 1npw]], [[ 1eby]], [[ 1ec0]], [[ 1g2k]], [[ 1c6x]], [[ 1c6y]], [[ 1c6z]], [[ 1hwr]], [[ 2bpv]], [[ 2bpw]], [[ 2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[ 1hvh]], [[ 3tlh]], [[ 1hxw]] - HIV1-PR + inhibitor<br />
[[1aid]], [[ 1qbr]], [[ 1qbs]], [[ 1qbt]], [[ 1qbu]], [[ 3mxe]], [[ 3m9f ]], [[ 3kf0]], [[ 3kf1]], [[ 3kfn]], [[ 3kfp]], [[ 3kfr]], [[ 3kfs]], [[ 2wkz]], [[ 2wl0]], [[ 3gga]], [[ 3ggv]], [[ 3ggx]], [[ 2uxz]], [[ 2uy0]], [[ 1zp8]], [[ 1xl2]], [[ 1xl5]], [[ 1zpa]], [[ 1yt9]], [[ 2a4f ]], [[ 1upj]], [[ 2upj]], [[ 7upj]], [[ 1hxb]], [[ 1hih]], [[ 1hvr]], [[ 1hef]], [[ 1heg]], [[ 4phv]], [[ 1w5w]], [[ 1w5x]], [[ 1w5v]], [[ 1w5y]], [[ 1t7k]], [[ 1npa]], [[ 1npv]], [[ 1npw]], [[ 1eby]], [[ 1ec0]], [[ 1g2k]], [[ 1c6x]], [[ 1c6y]], [[ 1c6z]], [[ 1hwr]], [[ 2bpv]], [[ 2bpw]], [[ 2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[ 1hvh]], [[ 3tlh]], [[ 1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]] - HIV1-PR + inhibitor<br />
[[2zye]] - HIV1-PR + inhibitor - neutron<br />
[[2zye]] - HIV1-PR + inhibitor - neutron<br />
[[3aid]], [[ 1ytg]], [[ 1yth]], [[ 2nxd]], [[ 2nxl]], [[ 2nxm]], [[ 2fns]], [[ 2fnt]], [[ 1zj7]], [[ 1zlf]], [[ 1zpk]], [[ 1zsf]], [[ 1zsr]],
[[3aid]], [[ 1ytg]], [[ 1yth]], [[ 2nxd]], [[ 2nxl]], [[ 2nxm]], [[ 2fns]], [[ 2fnt]], [[ 1zj7]], [[ 1zlf]], [[ 1zpk]], [[ 1zsf]], [[ 1zsr]],
[[1cpi]], [[ 1m0b]], [[ 1iiq]], [[ 1fqx]], [[ 1a30]] - HIV1-PR + polypeptide derivative<br />
[[1cpi]], [[ 1m0b]], [[ 1iiq]], [[ 1fqx]], [[ 1a30]] - HIV1-PR + polypeptide derivative<br />
[[3gi0]] - HIV1-PR covalent dimer + polypeptide<br />
[[3hzc]], [[3iaw]], [[3ka2]], [[3nxn]] - HIV1-PR covalent dimer + inhibitor<br />
[[1sp5]] - HIV1-PR + autoproteolytic peptide
[[1sp5]] - HIV1-PR + autoproteolytic peptide


===HIV-1 (mutant) complexes===
===HIV-1 (mutant) complexes===


[[3nu3]], [[ 3nu4]], [[ 3nu5]], [[ 3nu6]], [[ 3nu9]], [[ 3nuj]], [[ 3nuo]], [[ 2qhc]], [[ 2qak]], [[ 2pym]], [[ 2pyn]], [[ 2q63]], [[ 2q64]], [[ 2fxd]], [[ 2fxe]], [[ 2fgu]], [[ 2fgv]], [[ 1sdt]], [[ 1sdu]], [[ 1sdv]], [[ 1d4y]], [[ 1d4s]] - HIV1-PR (mutant) + antiviral drug<br />  
[[3nu3]], [[ 3nu4]], [[ 3nu5]], [[ 3nu6]], [[ 3nu9]], [[ 3nuj]], [[ 3nuo]], [[ 2qhc]], [[ 2qak]], [[ 2pym]], [[ 2pyn]], [[ 2q63]], [[ 2q64]], [[ 2fxd]], [[ 2fxe]], [[ 2fgu]], [[ 2fgv]], [[ 1sdt]], [[ 1sdu]], [[ 1sdv]], [[ 1d4y]], [[ 1d4s]], [[3cyw]], [[3cyx]], [[3d1x]], [[3d1y]], [[3d1z]], [[3d20]], [[3djk]], [[3dk1]], [[3n3i]], [[3oxv]], [[3oxw]], [[3oxx]], [[3oy4]], [[3k4v]], [[3lzs]], [[3lzu]], [[3lzv]], [[3so9]], [[3spk]] - HIV1-PR (mutant) + antiviral drug<br />  
[[2aid]], [[ 1hpo]], [[ 1tcx]], [[ 1gnm]], [[ 1gnn]], [[ 1gno]], [[ 1kzk]], [[ 3ok9]], [[ 3i8w]], [[ 3i7e]], [[ 3bxr]], [[ 3bxs]], [[ 2hc0]], [[ 2psu]], [[ 2psv]], [[ 2fle]], [[ 2f3k]], [[ 2ien]], [[ 2fdd]], [[ 2fde]], [[ 1t7i]], [[ 1t3r]], [[ 1mrw]], [[ 1mrx]], [[ 1msm]], [[ 1msn]], [[ 1bv9]] - HIV1-PR (mutant) + inhibitor<br />
[[2aid]], [[ 1hpo]], [[ 1tcx]], [[ 1gnm]], [[ 1gnn]], [[ 1gno]], [[ 1kzk]], [[ 3ok9]], [[ 3i8w]], [[ 3i7e]], [[ 3bxr]], [[ 3bxs]], [[ 2hc0]], [[ 2psu]], [[ 2psv]], [[ 2fle]], [[ 2f3k]], [[ 2ien]], [[ 2fdd]], [[ 2fde]], [[ 1t7i]], [[ 1t3r]], [[ 1mrw]], [[ 1mrx]], [[ 1msm]], [[ 1msn]], [[ 1bv9]], [[3h5b]], [[3kdb]], [[3kdc]], [[3kdd]], [[3a2o]], [[3bc4]], [[3fx5]], [[3i6o]], [[3st5]]- HIV1-PR (mutant) + inhibitor<br />
[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
[[1zbg]], [[ 1z8c]], [[ 2az9]], [[ 2azc]], [[ 2a1e]], [[ 1lzq]], [[ 1d4k]], [[ 1d4l]], [[ 1a8k]], [[ 1a94]], [[ 1axa]] - HIV1-PR (mutant) + polypeptide derivative<br />
[[1zbg]], [[ 1z8c]], [[ 2az9]], [[ 2azc]], [[ 2a1e]], [[ 1lzq]], [[ 1d4k]], [[ 1d4l]], [[ 1a8k]], [[ 1a94]], [[ 1axa]], [[3dox]], [[3d3t]] - HIV1-PR (mutant) + polypeptide derivative<br />
[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane
[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane<br />
[[3b7v]], [[3b80]], [[3mim]] - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate<br />
[[3nxe]] - HIV1-PR covalent dimer (mutant) + inhibitor


===HIV-1 (drug-resistant mutant) complexes===
===HIV-1 (drug-resistant mutant) complexes===


[[3el4]], [[ 3el9]], [[ 3em3]], [[ 3em4]], [[ 3em6]], [[ 3ggt]], [[ 3ggu]], [[ 1t7j]], [[ 1rv7]], [[ 1n49]], [[ 1fb7]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
[[3el4]], [[ 3el9]], [[ 3em3]], [[ 3em4]], [[ 3em6]], [[ 3ggt]], [[ 3ggu]], [[ 1t7j]], [[ 1rv7]], [[ 1n49]], [[ 1fb7]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekw]], [[3el0]], [[3el5]], [[3pwm]], [[3pwr]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br />
[[1izh]], [[ 1izi]], [[ 1fb7]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
[[1izh]], [[ 1izi]], [[ 1fb7]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
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[[2hah]], [[4fiv]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
[[2hah]], [[4fiv]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
[[3ogp]], [[3ogq]] - FIV-PR residues 39-154 (mutant) + drug<br />
[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
[[2fiv]], [[3fiv]] - SIV-PR (mutant) + substrate
[[2fiv]], [[3fiv]] - SIV-PR (mutant) + substrate
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===Human Cytomegalovirus protease===
===Human Cytomegalovirus protease===


[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus
[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus 5<br />
[[1wpo]] – CMVP
[[1wpo]] – CMVP<br />
[[2wpo]] - CMVP (mutant) + inhibitor
[[2wpo]] - CMVP (mutant) + inhibitor


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[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
===Orf 17===
[[3njq]] – hOrf 17 - human herpes virus 8
===Dengue virus protease===
[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
[[3u1j]] – DvNs2b + BPTI


[[Category:Topic Page]]
[[Category:Topic Page]]
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