2iut: Difference between revisions
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[[Image:2iut.gif|left|200px]]<br /><applet load="2iut" size=" | [[Image:2iut.gif|left|200px]]<br /><applet load="2iut" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2iut, resolution 2.25Å" /> | caption="2iut, resolution 2.25Å" /> | ||
'''P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC'''<br /> | '''P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2IUT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with MG and ATG as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Atg Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | 2IUT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ATG:'>ATG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Atg+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:38:26 2008'' | ||
Revision as of 08:38, 3 February 2008
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P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC
Overview
FtsK is a DNA translocase that coordinates chromosome segregation and cell, division in bacteria. In addition to its role as activator of XerCD, site-specific recombination, FtsK can translocate double-stranded DNA, (dsDNA) rapidly and directionally and reverse direction. We present, crystal structures of the FtsK motor domain monomer, showing that it has a, RecA-like core, the FtsK hexamer, and also showing that it is a ring with, a large central annulus and a dodecamer consisting of two hexamers, head, to head. Electron microscopy (EM) demonstrates the DNA-dependent existence, of hexamers in solution and shows that duplex DNA passes through the, middle of each ring. Comparison of FtsK monomer structures from two, different crystal forms highlights a conformational change that we propose, is the structural basis for a rotary inchworm mechanism of DNA, translocation.
About this Structure
2IUT is a Single protein structure of sequence from Pseudomonas aeruginosa with MG and ATG as ligands. Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Pseudomonas aeruginosa
- Single protein
- Lowe, J.
- Massey, T.H.
- Mercogliano, C.P.
- Sherratt, D.J.
- Yates, J.
- ATG
- MG
- Aaa atpase
- Atp-binding
- Cell cycle
- Cell division
- Chromosome partition
- Divisome
- Dna translocation
- Dna-binding
- Hexameric ring
- Inner membrane
- Kops
- Membrane
- Membrane protein
- Nucleotide-binding
- Transmembrane
