Sandbox 215: Difference between revisions

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[http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein Cholesteryl Ester Transfer Protein] is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2Å resolution in complex with four bound lipid molecules shows a long tunnel traversing the core of the molecule and has two distinct large openings allowing ~~lipid~~ access~~. This tunnel is plugged by an amphiphilic phosphatidylcholine at each end~~.

[http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein Cholesteryl Ester Transfer Protein] is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2Å resolution in complex with four bound lipid molecules shows a long tunnel traversing the core of the molecule and has two distinct large openings allowing lipids access.

==Role of CETP==

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CETP's structure can be divided into four structural units:

* At each end of the protein there is a barrel which is constitued of highly twisted B-sheet and two helices called A and B at the N-terminal and A', B' at C-terminal extremity. Helices B and B' are longer than A and A'

* At each end of the protein there is a barrel which is constitued of highly twisted ß-sheet and two helices called A and B at the N-terminal and A', B' at C-terminal extremity. Helices B and B' are longer than A and A'

* Between the two barrels there is a central B-sheet which is constitued of six antiparallel strands

* Between the two barrels there is a central ß-sheet which is constitued of six antiparallel strands

* At the C-terminal extremity there is a distorted amphiphathic helix called helix X which is an extension of C-teminal interacting with N-terminal residues.

Sandbox 215: Difference between revisions

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-[http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein Cholesteryl Ester Transfer Protein] is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2Å resolution in complex with four bound lipid molecules shows a long tunnel traversing the core of the molecule and has two distinct large openings allowing lipid access. This tunnel is plugged by an amphiphilic phosphatidylcholine at each end.
+[http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein Cholesteryl Ester Transfer Protein] is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2Å resolution in complex with four bound lipid molecules shows a long tunnel traversing the core of the molecule and has two distinct large openings allowing lipids access.
 ==Role of CETP==
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 CETP's structure can be divided into four structural units:
-* At each end of the protein there is a barrel which is constitued of highly twisted B-sheet and two helices called A and B at the N-terminal and A', B' at C-terminal extremity. Helices B and B' are longer than A and A'
+* At each end of the protein there is a barrel which is constitued of highly twisted ß-sheet and two helices called A and B at the N-terminal and A', B' at C-terminal extremity. Helices B and B' are longer than A and A'
-* Between the two barrels there is a central B-sheet which is constitued of six antiparallel strands
+* Between the two barrels there is a central ß-sheet which is constitued of six antiparallel strands
 * At the C-terminal extremity there is a distorted amphiphathic helix called helix X which is an extension of C-teminal interacting with N-terminal residues.