Sandbox 215: Difference between revisions
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Cholesteryl ester 2 penetrates deeper into the barrel than CE1 and resides between the central ß-sheet and the C-barrel. This site contains even fewer polar groups than CE1 binding site. That's why CE2 is not able to make any hydrogen-bonding or π-starking interaction. | Cholesteryl ester 2 penetrates deeper into the barrel than CE1 and resides between the central ß-sheet and the C-barrel. This site contains even fewer polar groups than CE1 binding site. That's why CE2 is not able to make any hydrogen-bonding or π-starking interaction. | ||
The N-opening of the tunnel is 10 Å wide and 5 Å high whereas the C-opening is 13 Å X 5 Å. The C-opening is a little bit larger but both are large enough to allow lipid access. | The N-opening of the tunnel is 10 Å wide and 5 Å high whereas the C-opening is 13 Å X 5 Å. The C-opening is a little bit larger but both are large enough to allow lipid access. | ||
Each opening of the tunnel is plugged by one phospholipid which buries its hydrophobic acyl chain inside the tunnel and its hydrophilic head groups to the solvent. | Each opening of the tunnel is plugged by one phospholipid which buries its hydrophobic acyl chain inside the tunnel and its hydrophilic head groups to the solvent. | ||
'''Helix X and Ω flaps''' | '''Helix X and Ω flaps''' | ||
Some mobile structures located near tunnel openings facilitate the lipid transfer. | Some mobile structures located near tunnel openings facilitate the lipid transfer. | ||
