Sandbox 210: Difference between revisions
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{{STRUCTURE_1h4l| PDB=1h4l | SCENE= }} | {{STRUCTURE_1h4l| PDB=1h4l | SCENE= }} | ||
CDK means Cyclin Dependent Kinase. The cyclin-dependent kinases (CDKs) are a large family of serine–threonine kinases which control the eukaryotic cell cycle, when they are activated by the cyclin regulatory subunit. These kinases phosphorylate a very large number of protein in order to inactivate or activate them.<ref>doi:10.1007/s00894-009-0629-4</ref> | CDK means Cyclin Dependent Kinase. The cyclin-dependent kinases (CDKs) are a large family of serine–threonine kinases which control the eukaryotic cell cycle, when they are activated by the cyclin regulatory subunit. These kinases phosphorylate a very large number of protein in order to inactivate or activate them.<ref>doi:10.1007/s00894-009-0629-4</ref> | ||
Cyclin dependent kinase 5 (CDK5) is a unique member of CDK family members that is not activated by a cyclin. Instead it is activated by a kinase, p35 also named Cyclin-dependent kinase 5 activator. Unlike other CDKs, it plays a major role in cell communication, cell morphology and motility. | |||
'''Cyclin dependent kinase 5'''(CDK5) is a unique member of CDK family members that is not activated by a cyclin. Instead it is activated by a kinase, p35 also named Cyclin-dependent kinase 5 activator. Unlike other CDKs, it plays a major role in cell communication, cell morphology and motility. | |||
CDK5 could form a complex with p25, an other protein. | CDK5 could form a complex with p25, an other protein. | ||
==Discovery of CDK5== | |||
Reported by four independent groups of scientists in 1992, Cdk5 had multiple names. A first group reported it as a neuronal Cdc2 like kinase (NCLK) characterized and cloned from rat brain c-DNA library as a Cdk that phosphorylates the lysine–serine–proline motif of neurofilaments. It was reported to have 58% amino acid sequence homology with mouse Cdk1 and 61% homology with human Cdk2. While looking for several Cdks, which play an important role in eukaryotic cell cycle, a second group found Cdk5/PSSALARE kinase (with an alpha C helix) among several other Cdks. A third group of scientists called the same molecule as brain proline-directed protein kinase (BPDK), reporting it in bovine brain with functional similarity to cdc2. In the same year, the fourth group named it as Tau protein kinase II (TPK II) associated with microtubules. Later in 1993, the nomenclature settled down to Cdk5 after identifying the 30 kDa protein subunit of the active enzyme.<ref>DOI 10.1007/s10571-007-9242-1</ref> | |||
==Structure== | ==Structure== | ||
