Sandbox207: Difference between revisions

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http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/

==Marqueur biologique==

The CRP concentration is a very useful nonspecific biochemical marker of inflammation and/or tissue damage. It is used since 1977 in the diagnosis and the supervision of the evolution of the infections, because the normalization of its rate is an indication that the infectious phenomenon is mastered. The C Reactive Protein is also a predictive biomarker for cardiovascular disease risk.

In healthy young adult, the median concentration of CRP is 0.8 mg/l. This value may increase from less than 50 μg/l to more than 500 mg/l (10,000-fold), following an acute-phase stimulus. After a single stimulus, serum concentration of CRP is rising above 5 mg/l by about 6 hours. This increase is proportional in the intensity of the inflammation. The peak is reached around 48 hours. When the stimulus ceases, the circulating CRP concentration falls rapidly.

It exists individual variability in baseline CRP, whether resulting from non-genetic or genetic factors. Indeed, a polymorphism in the CRP gene intron and promoter has been described, that cause perturbations to normal expression levels.

The intron of the gene of the CRP is formed by 278 nucleotides, containing a segment of 39 nucleotides rich in GT bases. This segment could be responsible for the training of the left-handed helix of the Z-form DNA of the CRP. The individuals possessing a particular allele combination have a lower concentration of the CRP. It is probably due to structural modifications of the DNA which would affect the transcription of the gene.

Within the promoter, several polymorphisms were discovered in transcription factor binding E-box sites, what would significantly seem to influence the rate of the CRP into the blood.

This variability should be accounted for when using the CRP as a predictive biomarker.

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@@ Line 28: / Line 28: @@
 http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/
+==Marqueur biologique==
+The CRP concentration is a very useful nonspecific biochemical marker of inflammation and/or tissue damage. It is used since 1977 in the diagnosis and the supervision of the evolution of the infections, because the normalization of its rate is an indication that the infectious phenomenon is mastered. The C Reactive Protein is also a predictive biomarker for cardiovascular disease risk.
+In healthy young adult, the median concentration of CRP is 0.8 mg/l. This value may increase from less than 50 μg/l to more than 500 mg/l (10,000-fold), following an acute-phase stimulus. After a single stimulus, serum concentration of CRP is rising above 5 mg/l by about 6 hours. This increase is proportional in the intensity of the inflammation. The peak is reached around 48 hours. When the stimulus ceases, the circulating CRP concentration falls rapidly.
+It exists individual variability in baseline CRP, whether resulting from non-genetic or genetic factors. Indeed, a polymorphism in the CRP gene intron and promoter has been described, that cause perturbations to normal expression levels.
+The intron of the gene of the CRP is formed by 278 nucleotides, containing a segment of 39 nucleotides rich in GT bases. This segment could be responsible for the training of the left-handed helix of the Z-form DNA of the CRP. The individuals possessing a particular allele combination have a lower concentration of the CRP. It is probably due to structural modifications of the DNA which would affect the transcription of the gene.
+Within the promoter, several polymorphisms were discovered in transcription factor binding E-box sites, what would significantly seem to influence the rate of the CRP into the blood.
+This variability should be accounted for when using the CRP as a predictive biomarker.