Sandbox 666: Difference between revisions

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There are several non-contiguous structural elements, which are involved in DNA recognition:
There are several non-contiguous structural elements, which are involved in DNA recognition:
- Four helix (two of each subunit) recognize the major groove and bring residues, whose interact with DNA bases and backbones
    Four helix (two of each subunit) recognize the major groove and bring residues, whose interact with DNA bases and backbones
- An extended peptide chain running through the major groove forms the specific contacts of the enzymes to the DNA.
    An extended peptide chain running through the major groove forms the specific contacts of the enzymes to the DNA.
- One ß-strand parallel to the DNA backbone, which contains amino acid residues essential for catalysis (e.g.: residues engaged in phosphate contacts)
    One ß-strand parallel to the DNA backbone, which contains amino acid residues essential for catalysis (e.g.: residues engaged in phosphate contacts)
- Two arms, which establish contacts with DNA backbones outside the recognition sequences.
    Two arms, which establish contacts with DNA backbones outside the recognition sequences.
This binding by the major groove is due to the position of scissile phosphodiester bonds.
This binding by the major groove is due to the position of scissile phosphodiester bonds.


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