Sandbox 215: Difference between revisions
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In the middle of the tunnel there is two cholesteryl esters binding sites. | In the middle of the tunnel there is two cholesteryl esters binding sites. | ||
*Cholesteryl ester 1 (CE1) is situated between the N barrel and the central β-sheet. This binding site is mostly constitued of hydrophobic residues and only a few polar. CE1 is not able to establish a hydrogen bond because the Ser 230 is too far away from CE1. However, CE1 can establish some π-starking interaction with the His232. | *Cholesteryl ester 1 (CE1) is situated between the N barrel and the central β-sheet. This binding site is mostly constitued of hydrophobic residues and only a few polar. CE1 is not able to establish a hydrogen bond because the <scene name='Sandbox_215/Ser230/1'>Ser 230</scene> is too far away from CE1. However, CE1 can establish some π-starking interaction with the His232. | ||
*Cholesteryl ester 2 (CE2) is situated between the central β-sheet and the C-barrel. CE2 penetrates deeper into the barrel than CE1. This site contains even fewer polar groups than CE1 binding site. That's why CE2 is not able to make any hydrogen-bonding or π-starking interaction. | *Cholesteryl ester 2 (CE2) is situated between the central β-sheet and the C-barrel. CE2 penetrates deeper into the barrel than CE1. This site contains even fewer polar groups than CE1 binding site. That's why CE2 is not able to make any hydrogen-bonding or π-starking interaction. | ||
