Sandbox 213: Difference between revisions
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<Structure load='3CLN' size='250' frame='true' align='left' caption='Calcium-bound calmodulin' scene='Insert optional scene name here' /> | <Structure load='3CLN' size='250' frame='true' align='left' caption='Calcium-bound calmodulin' scene='Insert optional scene name here' /> | ||
[[Calmodulin]] (CaM) for Calcium-Modulated protein is an important protein that intervenes in a wide range of activities inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, and the immune response.CaM is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. | [[Calmodulin]] (CaM) for Calcium-Modulated protein is an important protein that intervenes in a wide range of activities inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, and the immune response. | ||
CaM is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. | |||
Indeed,it is a small (16.7 kDa = 148 aa) and highly conserved protein that is necessary in all eukaryotic cells because it represents an essential calcium sensor with troponin C its isoform. ''' | Indeed,it is a small (16.7 kDa = 148 aa) and highly conserved protein that is necessary in all eukaryotic cells because it represents an essential calcium sensor with troponin C its isoform. ''' | ||
Calcium ions play a major role in the metabolism and physiology of eukaryotes cells, that's why calmodulin is important for the transport. | Calcium ions play a major role in the metabolism and physiology of eukaryotes cells, that's why calmodulin is important for the transport. | ||
Calmodulin contains four Ca<sup>2+</sup> binding sites''' and the binding of calcium induces a conformational change in calmodulin that can cause the activation of key enzymes such as kinases or phosphatases proteins (especially phosphorylase kinases) which are not necessarily themselves Ca<sup>2+</sup>-sensitive and allows a large diversity of cellular response. | Calmodulin contains four Ca<sup>2+</sup> binding sites''' and the binding of calcium induces a conformational change in calmodulin that can cause the activation of key enzymes such as kinases or phosphatases proteins (especially phosphorylase kinases) which are not necessarily themselves Ca<sup>2+</sup>-sensitive and allows a large diversity of cellular response. | ||
