Sandbox 213: Difference between revisions

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*'''Three-dimensional structure of apocalmodulin'''

In the absence of bound Ca<sup>2+</sup>, the helices of calmodulin pack so that their hydrophobic side chains are not exposed. In this form it is unable to interact with its targets. Apocalmodulin (ApoCaM) binds to other proteins and has other specific effects. It is essential role for life. The ApoCaM-binding proteins are a diverse group of at least 15 proteins including enzymes, actin-binding proteins, as well as cytoskeletal and other membrane proteins, including receptors and ion channels.

In the absence of bound Ca<sup>2+</sup>, the helices of calmodulin pack so that their hydrophobic side chains are not exposed. In this form it is unable to interact with its targets.The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the motif (GxxxR).

Apocalmodulin (ApoCaM) binds to other proteins and has other specific effects. It is essential role for life. The ApoCaM-binding proteins are a diverse group of at least 15 proteins including enzymes, actin-binding proteins, as well as cytoskeletal and other membrane proteins, including receptors and ion channels.

<ref name="Najl V Valeyev1, Declan G Bates1, Pat Heslop-Harrison1,2, Ian Postlethwaite1 and Nikolay V Kotov. Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach.BMC Systems Biology 2008, 2:48 doi:[[10.1186/1752-0509-2-48]]"/>.

Sandbox 213: Difference between revisions

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@@ Line 42: / Line 42: @@
 *'''Three-dimensional structure of apocalmodulin'''
 <Structure load='1CLL' size='300' frame='true' align='RIGHT' caption='Insert caption here' scene='Insert optional scene name here' />
-In the absence of bound Ca<sup>2+</sup>, the helices of calmodulin pack so that their hydrophobic side chains are not exposed. In this form it is unable to interact with its targets. Apocalmodulin (ApoCaM) binds to other proteins and has other specific effects. It is essential role for life. The ApoCaM-binding proteins are a diverse group of at least 15 proteins including enzymes, actin-binding proteins, as well as cytoskeletal and other membrane proteins, including receptors and ion channels.
+In the absence of bound Ca<sup>2+</sup>, the helices of calmodulin pack so that their hydrophobic side chains are not exposed. In this form it is unable to interact with its targets.The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the motif (GxxxR).
+Apocalmodulin (ApoCaM) binds to other proteins and has other specific effects. It is essential role for life. The ApoCaM-binding proteins are a diverse group of at least 15 proteins including enzymes, actin-binding proteins, as well as cytoskeletal and other membrane proteins, including receptors and ion channels.
 <ref name="Najl V Valeyev1, Declan G Bates1, Pat Heslop-Harrison1,2, Ian Postlethwaite1 and Nikolay V Kotov. Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach.BMC Systems Biology 2008, 2:48 doi:[[10.1186/1752-0509-2-48]]"/>.