Sandbox207: Difference between revisions
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The intron of the gene of the CRP is formed by 278 nucleotides, containing a segment of 39 nucleotides rich in GT bases. This segment could be responsible for the training of the left-handed helix of the Z-form DNA of the CRP. The individuals possessing a particular allele combination have a lower concentration of the CRP. It is probably due to structural modifications of the DNA which would affect the transcription of the gene. | The intron of the gene of the CRP is formed by 278 nucleotides, containing a segment of 39 nucleotides rich in GT bases. This segment could be responsible for the training of the left-handed helix of the Z-form DNA of the CRP. The individuals possessing a particular allele combination have a lower concentration of the CRP. It is probably due to structural modifications of the DNA which would affect the transcription of the gene. | ||
:Within the promoter, several polymorphisms were discovered in transcription factor binding E-box sites, what seem to | :Within the promoter, several polymorphisms were discovered in transcription factor binding E-box sites, what seem to significantly influence the rate of the CRP into the blood. | ||
:This variability should be taken into account when using the CRP as a predictive biomarker. | :This variability should be taken into account when using the CRP as a predictive biomarker. | ||
