Sandbox207: Difference between revisions
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:The CRP gene is located on chromosome 1q23. It is composed of two exons and one intron. This gene is regulated by interleukin-6, the principal inducer of the gene during the acute phase. CRP is secreted by hepatocytes.[http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx] | :The CRP gene is located on chromosome 1q23. It is composed of two exons and one intron. This gene is regulated by interleukin-6, the principal inducer of the gene during the acute phase. CRP is secreted by hepatocytes.[http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx] | ||
:The Human CRP belongs to the pentraxin family of proteins having five identical, non-covalently associated subunits that form a symmetrical homopentameric ring. The pentraxin family is highly conserved in evolution. | :The Human CRP belongs to the pentraxin family of proteins having five identical, non-covalently associated subunits that form a symmetrical homopentameric ring. The pentraxin family is highly conserved in evolution.[http://www.jci.org/articles/view/18921] | ||
===Size=== | ===Size=== | ||
:Each subunit contains 206 amino acid residues (approximately 23kDa) and is non-glycosylated. The outside diameter of the pentamer is 102 Å, the diameter of the inner core is 30 Å, and the diameter of the protomer is 36 Å. [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/] | :Each subunit contains 206 amino acid residues (approximately 23kDa) and is non-glycosylated. The outside diameter of the pentamer is 102 Å, the diameter of the inner core is 30 Å, and the diameter of the protomer is 36 Å. [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/] | ||
===Detailed strucutre=== | ===Detailed strucutre=== | ||
