Sandbox207: Difference between revisions

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==CRP, C-reactive Protein==

The C Reactive Protein is a protein of acute phase, the first described, exclusively synthetized by the liver.

The C Reactive Protein is a protein of the '''acute phase''', the first described, exclusively synthetized by the liver.

The CRP was first isolated by Tillett and France in 1930, in patients' serum presenting an acute inflammation. This protein reacted to the polysaccharide C of the pneumocoque, ~~ce qui lui valut son nom~~. [http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <1>]

The CRP was first isolated by '''Tillett and France in 1930''', in patients' serum presenting an acute inflammation. This protein reacted to the '''polysaccharide C''' of the pneumocoque, that is where its name comes from. [http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <1>]

The CRP contributes to innate host defense, and plays an important role in ~~the~~ inflammatory reactions. It can bind to specific molecular configurations typically exposed during cell death or found on the surfaces of pathogens. It is used as biological marker to reveal an inflammatory reaction and tissue damage. [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/ <2>]

The CRP contributes to innate host defense, and plays an important role in inflammatory reactions. It can bind to specific molecular configurations typically exposed during cell death or found on the surfaces of pathogens. It is used as '''biological marker''' to reveal an inflammatory reaction and tissue damage. [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/ <2>]

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===Gene structure, family===

:The CRP gene is located on chromosome 1q23. It is composed of two exons and one intron. This gene is regulated by interleukin-6, the principal inducer of the gene during the acute phase. CRP is secreted by hepatocytes.[http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <5>]

:The CRP gene is located on '''chromosome 1q23'''. It is composed of '''two exons''' and '''one intron'''. This gene is regulated by interleukin-6, the principal inducer of the gene during the acute phase. CRP is secreted by '''hepatocytes'''.[http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <5>]

:The Human CRP belongs to the pentraxin family of proteins having five identical, non-covalently associated subunits that form a symmetrical homopentameric ring. The pentraxin family is highly conserved in evolution.[http://www.jci.org/articles/view/18921 <3>]

:The Human CRP belongs to the '''pentraxin family''' , proteins having five identical, non-covalently associated subunits that form a symmetrical '''homopentameric ring'''. The pentraxin family is highly conserved in evolution.[http://www.jci.org/articles/view/18921 <3>]

===Size===

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@@ Line 11: / Line 11: @@
 ==CRP, C-reactive Protein==
-The C Reactive Protein is a protein of acute phase, the first described, exclusively synthetized by the liver.
+The C Reactive Protein is a protein of the '''acute phase''', the first described, exclusively synthetized by the liver.
-The CRP was first isolated by Tillett and France in 1930, in patients' serum presenting an acute inflammation. This protein reacted to the polysaccharide C of the pneumocoque, ce qui lui valut son nom. [http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <1>]
+The CRP was first isolated by '''Tillett and France in 1930''', in patients' serum presenting an acute inflammation. This protein reacted to the '''polysaccharide C''' of the pneumocoque, that is where its name comes from. [http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <1>]
-The CRP contributes to innate host defense, and plays an important role in the inflammatory reactions. It can bind to specific molecular configurations typically exposed during cell death or found on the surfaces of pathogens. It is used as biological marker to reveal an inflammatory reaction and tissue damage. [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/ <2>]
+The CRP contributes to innate host defense, and plays an important role in inflammatory reactions. It can bind to specific molecular configurations typically exposed during cell death or found on the surfaces of pathogens. It is used as '''biological marker''' to reveal an inflammatory reaction and tissue damage. [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/ <2>]
@@ Line 22: / Line 22: @@
 ===Gene structure, family===
-:The CRP gene is located on chromosome 1q23. It is composed of two exons and one intron. This gene is regulated by interleukin-6, the principal inducer of the gene during the acute phase. CRP is secreted by hepatocytes.[http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <5>]
+:The CRP gene is located on '''chromosome 1q23'''. It is composed of '''two exons''' and '''one intron'''. This gene is regulated by interleukin-6, the principal inducer of the gene during the acute phase. CRP is secreted by '''hepatocytes'''.[http://www.rndsystems.com/cb_detail_objectname_SU05_CReactiveProtein.aspx <5>]
-:The Human CRP belongs to the pentraxin family of proteins having five identical, non-covalently associated subunits that form a symmetrical homopentameric ring. The pentraxin family is highly conserved in evolution.[http://www.jci.org/articles/view/18921 <3>]
+:The Human CRP belongs to the '''pentraxin family''' , proteins having five identical, non-covalently associated subunits that form a symmetrical '''homopentameric ring'''. The pentraxin family is highly conserved in evolution.[http://www.jci.org/articles/view/18921 <3>]
 ===Size===