Sandbox207: Difference between revisions
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Elise Rosati (talk | contribs) No edit summary |
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===Detailed strucutre=== | ===Detailed strucutre=== | ||
:Each protomer consists of two '''anti-parallel β sheets''' (the lectin fold) with an '''α helix''' on the effector face of the protein. The ligand biding site is located on the concave face of the protein, and is composed of loops with '''2 calcium ions''' bound 4 Å apart by protein side-chains. | :Each protomer consists of two '''anti-parallel β sheets''' (the lectin fold) with an '''α helix''' on the effector face of the protein. The ligand biding site is located on the concave face of the protein, and is composed of loops with '''2 calcium ions''' bound 4 Å apart by protein side-chains. | ||
:The recognition face contains the | :The recognition face contains the phosphocholine binding site which consists of two coordinated calcium ions next to a '''hydrophobic pocket''' in which the phosphocholine stays. | ||
:There are interprotomer interactions between the subunits: '''three salt bridges''' are included and the 115-123 loop of one protomer and the 40-42 and 197-202 regions of adjacent protomers are involved. Moreover, the subunits can rotate by 15-20° around an axis parallel to the central alpha-helix. | :There are interprotomer interactions between the subunits: '''three salt bridges''' are included and the 115-123 loop of one protomer and the 40-42 and 197-202 regions of adjacent protomers are involved. Moreover, the subunits can rotate by 15-20° around an axis parallel to the central alpha-helix. | ||
