Sandbox207: Difference between revisions
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<Structure load='1b09' size='250' frame='true' align='right' caption='CRP complexed with Phosphocholine' scene='CRPcwp' /> | <Structure load='1b09' size='250' frame='true' align='right' caption='CRP complexed with Phosphocholine' scene='CRPcwp' /> | ||
:In the presence of calcium, CRP is '''specifically''' bound to phosphocholine residues. We find phosphocholine in the microbial polysaccharides. | :In the presence of calcium, CRP is '''specifically''' bound to <scene name='Sandbox207/Phosphocholine/6'>phosphocholine </scene> residues. We find phosphocholine in the microbial polysaccharides. | ||
:The wide distribution of phosphocholine in polysaccharides of pathogenic and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as the damaged membranes and necrosed cells of the host. The ligand, the phosphocholine, does not appear normally on the surface of cells, but '''is exposed by cellular damages caused by phospholipases'''. | :The wide distribution of phosphocholine in polysaccharides of pathogenic and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as the damaged membranes and necrosed cells of the host. The ligand, the phosphocholine, does not appear normally on the surface of cells, but '''is exposed by cellular damages caused by phospholipases'''. | ||
:After this connection, CRP activates the '''classical complement pathway''' in the absence of antibody, and '''opsonizes ligands''', with the aim of their phagocytosis. | :After this connection, CRP activates the '''classical complement pathway''' in the absence of antibody, and '''opsonizes ligands''', with the aim of their phagocytosis. | ||
