2rft: Difference between revisions

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[[Image:2rft.jpg|left|200px]]<br /><applet load="2rft" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2rft" />

caption="2rft, resolution 2.80Å" />

''''''<br />

'''Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog'''<br />

==Overview==

Receptor-binding specificity of HA, the major surface glycoprotein of, influenza virus, primarily determines the host ranges that the virus can, infect. Influenza type B virus almost exclusively infects humans and, contributes to the annual "flu" sickness. Here we report the structures of, influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide a structural basis for the, different receptor-binding properties of influenza A and B virus HA, molecules and for the ability of influenza B virus HA to distinguish human, and avian receptors. The structure of influenza B virus HA with avian, receptor analog also reveals how mutations in the region of residues 194, to 196, which are frequently observed in egg-adapted and naturally, occurring variants, directly affect the receptor binding of the resultant, virus strains. Furthermore, these structures of influenza B virus HA are, compared with known structures of influenza A virus HAs, which suggests, the role of the residue at 222 as a key and likely a universal determinant, for the different binding modes of human receptor analogs by different HA, molecules.

==About this Structure==

is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA].

2RFT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+343'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+345'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+A+346'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+347'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+348'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+349'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+A+350'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Residue+A+351'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+B+170'>AC9</scene>, <scene name='pdbsite=BC1:Sia+Binding+Site+For+Residue+A+3021'>BC1</scene>, <scene name='pdbsite=BC2:Bgc+Binding+Site+For+Residue+A+3025'>BC2</scene>, <scene name='pdbsite=BC3:Gal+Binding+Site+For+Residue+A+3024'>BC3</scene>, <scene name='pdbsite=BC4:Ndg+Binding+Site+For+Residue+A+3023'>BC4</scene> and <scene name='pdbsite=BC5:Gal+Binding+Site+For+Residue+A+3022'>BC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFT OCA].

==Reference==

Structural basis for receptor specificity of influenza B virus hemagglutinin., Wang Q, Tian X, Chen X, Ma J, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16874-9. Epub 2007 Oct 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17942670 17942670]

[[Category: Influenza b virus]]

[[Category: Protein complex]]

[[Category: Chen, X.]]

[[Category: Ma, J.]]

[[Category: Tian, X.]]

[[Category: Wang, Q.]]

[[Category: NAG]]

[[Category: envelope protein]]

[[Category: fusion protein]]

[[Category: glycoprotein]]

[[Category: hemagglutinin]]

[[Category: influenza]]

[[Category: lipoprotein]]

[[Category: membrane]]

[[Category: palmitate]]

[[Category: receptor specificity]]

[[Category: transmembrane]]

[[Category: viral protein]]

[[Category: virion]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 6 15:35:39 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 6 17:24:11 2008''

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@@ Line 1: / Line 1: @@
 [[Image:2rft.jpg|left|200px]]<br /><applet load="2rft" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2rft" />
+caption="2rft, resolution 2.80&Aring;" />
-''''''<br />
+'''Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog'''<br />
+==Overview==
+Receptor-binding specificity of HA, the major surface glycoprotein of, influenza virus, primarily determines the host ranges that the virus can, infect. Influenza type B virus almost exclusively infects humans and, contributes to the annual "flu" sickness. Here we report the structures of, influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide a structural basis for the, different receptor-binding properties of influenza A and B virus HA, molecules and for the ability of influenza B virus HA to distinguish human, and avian receptors. The structure of influenza B virus HA with avian, receptor analog also reveals how mutations in the region of residues 194, to 196, which are frequently observed in egg-adapted and naturally, occurring variants, directly affect the receptor binding of the resultant, virus strains. Furthermore, these structures of influenza B virus HA are, compared with known structures of influenza A virus HAs, which suggests, the role of the residue at 222 as a key and likely a universal determinant, for the different binding modes of human receptor analogs by different HA, molecules.
 ==About this Structure==
- is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA].
+RFT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+343'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+345'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+A+346'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+347'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+348'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+349'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+A+350'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Residue+A+351'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+B+170'>AC9</scene>, <scene name='pdbsite=BC1:Sia+Binding+Site+For+Residue+A+3021'>BC1</scene>, <scene name='pdbsite=BC2:Bgc+Binding+Site+For+Residue+A+3025'>BC2</scene>, <scene name='pdbsite=BC3:Gal+Binding+Site+For+Residue+A+3024'>BC3</scene>, <scene name='pdbsite=BC4:Ndg+Binding+Site+For+Residue+A+3023'>BC4</scene> and <scene name='pdbsite=BC5:Gal+Binding+Site+For+Residue+A+3022'>BC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFT OCA].
+==Reference==
+Structural basis for receptor specificity of influenza B virus hemagglutinin., Wang Q, Tian X, Chen X, Ma J, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16874-9. Epub 2007 Oct 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17942670 17942670]
+[[Category: Influenza b virus]]
 [[Category: Protein complex]]
+[[Category: Chen, X.]]
+[[Category: Ma, J.]]
+[[Category: Tian, X.]]
+[[Category: Wang, Q.]]
+[[Category: NAG]]
+[[Category: envelope protein]]
+[[Category: fusion protein]]
+[[Category: glycoprotein]]
+[[Category: hemagglutinin]]
+[[Category: influenza]]
+[[Category: lipoprotein]]
+[[Category: membrane]]
+[[Category: palmitate]]
+[[Category: receptor specificity]]
+[[Category: transmembrane]]
+[[Category: viral protein]]
+[[Category: virion]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  6 15:35:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  6 17:24:11 2008''