Large T Antigen: Difference between revisions
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Binding of large T antigen at the origin of replication allows replicative machinery to unwind and synthesize new DNA. Residues involved in DNA binding also bind ssDNA-binding protein human RPA<ref>PMID:2600586</ref>. T antigen also acts as a repressor of early gene transcription. When increased amounts of T antigen are present, it binds DNA and blocks the overlapping promoter sequence, thus behaving as its own regulator.</Structuresection> | Binding of large T antigen at the origin of replication allows replicative machinery to unwind and synthesize new DNA. Residues involved in DNA binding also bind ssDNA-binding protein human RPA<ref>PMID:2600586</ref>. T antigen also acts as a repressor of early gene transcription. When increased amounts of T antigen are present, it binds DNA and blocks the overlapping promoter sequence, thus behaving as its own regulator.</Structuresection> | ||
{{STRUCTURE_1svm| PDB=1svm | SIZE=400| SCENE= |right|CAPTION=SV40 large tumor antigen complexed with ATP, Zn+2 and Mg+2 ions, [[1svm]] }} | {{STRUCTURE_1svm| PDB=1svm | SIZE=400| SCENE= |right|CAPTION=SV40 large tumor antigen complexed with ATP, Zn+2 and Mg+2 ions, [[1svm]] }} | ||
