Aerolysin: Difference between revisions
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[[Image:1pre.png|left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]]]] | [[Image:1pre.png|left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]]]] | ||
{{STRUCTURE_1pre| PDB=1pre | SIZE= | {{STRUCTURE_1pre| PDB=1pre | SIZE=400| SCENE=Aerolysin/Cv/1 |right|CAPTION=Proaerolysin [[1pre]] }} | ||
[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, ''i.e.'' the crystal structure of Proaerolysin ([[1pre]]). | [[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, ''i.e.'' the crystal structure of Proaerolysin ([[1pre]]). For toxins in Proteopedia see [[Toxins]]. | ||
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Revision as of 11:45, 19 February 2012
Aerolysin (Aer) is a channel-forming toxin from Aeromonas hydrophyla. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, i.e. the crystal structure of Proaerolysin (1pre). For toxins in Proteopedia see Toxins.
3D Structures of Aerolysin
Aerolysin
Proaerolysin
1pre - proAer
3c0m, 3c0n, 1z52 - proAer (mutant)
3c0o - proAer (mutant)+mannose-6-phosphate
