Sandbox Reserved 427: Difference between revisions
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===Binding Interactions=== | ===Binding Interactions=== | ||
2dtg | |||
transmembrane receptor activated in the presence of insulin, a member of the tyrosine kinase class of receptor proteins | |||
Tyrosine Kinases in General | |||
Class of receptor proteins that add a phosphate group to a tyrosine on their specific substrate. | |||
Interactions with insulin (IRS-1) and subsequent binding/phosphorylation. This leads to an increase in the glucose transporter (Glut-4) which has a high affinity for glucose molecules. This occurs mainly in muscle and adipose tissues where glucose uptake is most needed. This increase in Glut-4 causes an increase in glucose uptake from blood. Simply stated, 2dtg is activated by insulin which signals for an increase in Glut-4. Glut-4 finds its way to the cell surface where it can perform its function (transport glucose into the cell). | |||
Green scene of the active site of 2dtg (tyrosine kinase) | |||
===Additional Features=== | ===Additional Features=== | ||
