Sandbox Reserved 430: Difference between revisions
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===Additional Features=== | ===Additional Features=== | ||
Cisplatin 1,2 intrastrand cross links DNA. | |||
It distorts the DNA duplex and allows recognition and binding by HMG-domain proteins. | |||
The interstrand cross link (18,19) was found to have created a localized change in DNA from being right handed B DNA to left handed Z- DNA. <scene name='Sandbox_Reserved_430/18_19/1'>18 19</scene> | |||
The 1,2 intrastrand cross links shows that the double helix forms a major groove at the site (20,21), the platinum coordination site. | |||
===Credits=== | ===Credits=== | ||
