Sandbox Reserved 425: Difference between revisions
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-22q11.2 deletion syndrome is a deletion of a small piece of chromosome 22. | -22q11.2 deletion syndrome is a deletion of a small piece of chromosome 22. | ||
- | |||
-chromosomal region that was deleted contains 30 to 40 genes including the COMT gene | |||
As a result of the deletion: | As a result of the deletion: | ||
- people who has this disorder have only one copy of the COMT gene in each cell | - people who has this disorder have only one copy of the COMT gene in each cell | ||
-A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain | -A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain | ||
-People with 22q11.2 deletion syndrome are more likely to develop one of these syndrome: schizophrenia, depression, anxiety, and bipolar disorder. | -People with 22q11.2 deletion syndrome are more likely to develop one of these syndrome: schizophrenia, depression, anxiety, and bipolar disorder. | ||
Variations in the COMT gene: | Variations in the COMT gene: | ||
- mental illness in people without 22q11.2 deletion syndrome. | - mental illness in people without 22q11.2 deletion syndrome. | ||
- the risk of developing schizophrenia | - the risk of developing schizophrenia | ||
-the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase | -the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase | ||
