Sandbox 37: Difference between revisions

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==Structure==
==Structure==
<StructureSection load='1IFA' size='400' align='right' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/1'></StructureSection>


Interferon-β is a relatively simple biological response modifier consisting of five <scene name='Sandbox_37/Ifnb_alpha_helices/1'>alpha helices</scene>. There are no beta sheets, but, in addition to the alpha helices, only multiple interconnecting <scene name='Sandbox_37/Ifnb_loops/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices.
<Structure load='1IFA' size='400' frame='true' align='center' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/1' />
 
Interferon-β is a relatively simple biological response modifier, with several <scene name='Sandbox_37/Interferon_beta/2'>identifiable regions</scene>. It consists of five <scene name='Sandbox_37/Ifnb_alpha_helices/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Sandbox_37/Ifnb_loops/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices.
<ref name="Structure">PMID:20616576</ref>
<ref name="Structure">PMID:20616576</ref>


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==Inhibition==
==Inhibition==
<Structure load='1IFA' size='400' frame='true' align='right' caption='Papain with leupeptin inhibitor (1IFA)' scene='Sandbox_37/Interferon_beta/2'/>
 
===Inhibitors of Interferon-β===
===Inhibitors of Interferon-β===
===Interferon-β as an Inhibitor===
===Interferon-β as an Inhibitor===