Sandbox 37: Difference between revisions

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<Structure load='1IFA' size='400' frame='true' align='center' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/1' />
<Structure load='1IFA' size='400' frame='true' align='center' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/1' />


Interferon-β is a relatively simple biological response modifier, with several <scene name='Sandbox_37/Interferon_beta/2'>identifiable regions</scene>. It consists of five <scene name='Sandbox_37/Ifnb_alpha_helices/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Sandbox_37/Ifnb_loops/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices.
Interferon-β is a relatively simple biological response modifier, with several <scene name='Sandbox_37/Interferon_beta/2'>identifiable regions</scene>. It consists of five <scene name='Sandbox_37/Ifnb_helices_in_color/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Sandbox_37/Ifnb_loopregions_in_color/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices.
<ref name="Structure">PMID:20616576</ref>
<ref name="Structure">PMID:20616576</ref>


Revision as of 00:55, 14 March 2012

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

Interferon-β

Introduction

Interferon-β is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.[1]

History

Structure

Interferon-β

Drag the structure with the mouse to rotate

Interferon-β is a relatively simple biological response modifier, with several identifiable regions. It consists of five alpha helices, as well as multiple interconnecting loop regions. Helices A, B and D run parallel to one another, and helices C and E run anti-parallel to the other three helices. [2]

[3]

Solvent Interactions

Mechanism

Inhibition

Inhibitors of Interferon-β

Interferon-β as an Inhibitor

Function

Biochemical

Immunological

References

  1. ↑ Voet, D., Voet, J.G., and C. Pratt. Fundamentals of Biochemistry 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.
  2. ↑ Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222
  3. ↑ https://www.uniprot.org/uniprot/P00784
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