Polyamine oxidase: Difference between revisions
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{{STRUCTURE_3l1r| PDB=3l1r | SIZE=400| SCENE= |right|CAPTION=Yeast polyamine oxidase Fms1 complex with spermidine, [[3l1r]] }} | {{STRUCTURE_3l1r| PDB=3l1r | SIZE=400| SCENE= |right|CAPTION=Yeast polyamine oxidase Fms1 complex with spermidine, sulfate and chloride ion, [[3l1r]] }} | ||
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Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | ||
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'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide. PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death. PAO is involved in polyamine catabolism and uses FAD as a cofactor. | '''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide. PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death. PAO is involved in polyamine catabolism and uses FAD as a cofactor. | ||
==3D structures of polyamine oxidase== | |||
[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br /> | [[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br /> | ||
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[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br /> | [[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br /> | ||
[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br /> | [[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br /> | ||
[[3l1r]] - | [[3l1r]] - mPAO (mutant) FAD-binding domain + spermidine | ||
