2yim: Difference between revisions
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===The enolisation chemistry of a thioester-dependent racemase: the 1.4 A crystal structure of a complex with a planar reaction intermediate analogue=== | |||
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{{ABSTRACT_PUBMED_22360758}} | |||
==About this Structure== | |||
[[2yim]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022360758</ref><ref group="xtra">PMID:017320106</ref><references group="xtra"/> | |||
[[Category: Alpha-methylacyl-CoA racemase]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Bhaumik, P.]] | |||
[[Category: Conzelmann, E.]] | |||
[[Category: Hiltunen, J K.]] | |||
[[Category: Juffer, A H.]] | |||
[[Category: Sharma, S.]] | |||
[[Category: Venkatesan, R.]] | |||
[[Category: Wierenga, R K.]] | |||
[[Category: Isomerase]] | |||
[[Category: Methyl-coa racemase]] | |||
[[Category: Molecular dynamic]] | |||
[[Category: Oxyanion hole]] | |||
[[Category: Qm/mm]] | |||
[[Category: Transition state]] | |||
Revision as of 07:39, 28 March 2012
The enolisation chemistry of a thioester-dependent racemase: the 1.4 A crystal structure of a complex with a planar reaction intermediate analogue
Template:ABSTRACT PUBMED 22360758
About this Structure
2yim is a 4 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Sharma S, Bhaumik P, Schmitz W, Venkatesan R, Hiltunen JK, Conzelmann E, Juffer AH, Wierenga RK. The Enolization Chemistry of a Thioester-Dependent Racemase: The 1.4 A Crystal Structure of a Reaction Intermediate Complex Characterized by Detailed QM/MM Calculations. J Phys Chem B. 2012 Mar 22;116(11):3619-29. Epub 2012 Mar 7. PMID:22360758 doi:10.1021/jp210185m
- Bhaumik P, Schmitz W, Hassinen A, Hiltunen JK, Conzelmann E, Wierenga RK. The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface. J Mol Biol. 2007 Apr 6;367(4):1145-61. Epub 2007 Jan 27. PMID:17320106 doi:https://dx.doi.org/10.1016/j.jmb.2007.01.062
