Lipase: Difference between revisions

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<scene name='Lipase/Substrate_contacts/1'>substrates contacts with cholesteryl linoleate</scene>
<scene name='Lipase/Substrate_contacts/1'>substrates contacts with cholesteryl linoleate</scene>


Seen here is the Candida rugosa lipase in <scene name='Sandbox_40/Complex_2/1'>complex</scene> with two molecules of cholesteryl linoleate (grey).
Seen here is the Candida rugosa lipase in  
<scene name='Lipase/Complex_2/1'>complex</scene> with two molecules of cholesteryl linoleate (grey).




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Pancreatic lipase is secreted into the duodenum through the duct system of the pancreas. In a healthy individual, it is in very low concentration in serum. Under extreme disruption of pancreatic function, such as pancreatitis or pancreatic cancer, the pancreas may begin to digest itself and release pancreatic enzymes including pancreatic lipase into serum. Measurement of serum concentration of pancreatic lipase can therefore aid in diagnosis of acute pancreatitis.<ref>"Pancreatic lipase". Wikipedia: The Free Encyclopedia. 7 Nov 2011 [http://en.wikipedia.org/wiki/Pancreatic_lipase]</ref>
Pancreatic lipase is secreted into the duodenum through the duct system of the pancreas. In a healthy individual, it is in very low concentration in serum. Under extreme disruption of pancreatic function, such as pancreatitis or pancreatic cancer, the pancreas may begin to digest itself and release pancreatic enzymes including pancreatic lipase into serum. Measurement of serum concentration of pancreatic lipase can therefore aid in diagnosis of acute pancreatitis.<ref>"Pancreatic lipase". Wikipedia: The Free Encyclopedia. 7 Nov 2011 [http://en.wikipedia.org/wiki/Pancreatic_lipase]</ref>


Here, lipase and colipase can be seen <scene name='Sandbox_47/Lipasecolipasesubstrate/1'>in complex with a triacylglycerol</scene>
Here, lipase and colipase can be seen <scene name='Lipase/Lipasecolipasesubstrate/1'>lipase and colipase with substrate</scene>


The N-terminal domain also contains a <scene name='Sandbox_47/Lid/1'>"lid"</scene> that blocks solvent from entering the active site.
The N-terminal domain also contains a <scene name='Lipase/Lid/1'>lid</scene> that blocks solvent from entering the active site.