Sandbox 34: Difference between revisions
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===Human Stefin B=== | ===Human Stefin B=== | ||
Other inhibitors, such as <scene name='Sandbox_34/Pap_1stf/1'>human stefin B</scene>, illustrated in magenta, are much more complex in their <scene name='Sandbox_34/Pap_1stf/5'>inhibition</scene>. The human stefin B molecule has a five stranded beta-sheet that wraps around a five turn alpha-helix. The interface between human stefin B and papain is very tightly packed with 16% of stefin B becoming embedded within papain. A total of 128 <scene name='Sandbox_34/Pap_1stf/6'>intermolecular atom-atom interactions</scene> <4 A occur within the cleft in papain, although only CYS25 interacts with the inhibitor. In this figure, the residues of interaction for stefin B are shown in red, the residues of interaction for papain are shown in blue, and the residues of papain's active site are shown in green. Through this study, Stubbs et al. were able to conclude that cysteine proteinase inhibitors are "fundamentally different to [those] observed for serine proteinase inhibitors."<ref>PMID:2347312</ref> | Other inhibitors, such as <scene name='Sandbox_34/Pap_1stf/1'>human stefin B</scene>, illustrated in magenta, are much more complex in their <scene name='Sandbox_34/Pap_1stf/5'>inhibition</scene>. The human stefin B molecule has a five stranded beta-sheet that wraps around a five turn alpha-helix. The interface between human stefin B and papain is very tightly packed with 16% of stefin B becoming embedded within papain. A total of 128 <scene name='Sandbox_34/Pap_1stf/6'>intermolecular atom-atom interactions</scene> <4 A occur within the cleft in papain, although only CYS25 interacts with the inhibitor. In this figure, the residues of interaction for stefin B are shown in red, the residues of interaction for papain are shown in blue, and the residues of papain's active site are shown in green. Through this study, Stubbs et al. were able to conclude that cysteine proteinase inhibitors are "fundamentally different to [those] observed for serine proteinase inhibitors."<ref>PMID:2347312</ref> | ||
<scene name='Sandbox_34/Subunitsrandl/4'>Planar circles at the voronoi surface</scene> | |||
== References == | == References == | ||
