Multiple sclerosis: Difference between revisions
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Interferons alpha and beta interact with a receptor at the surface of <ref>[http://www.jbc.org/content/282/28/20045.full?sid=cbf08059-44d4-4957-8ea7-0351cab9c2ac] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." ''J Biol Chem'' 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200</ref> | Interferons alpha and beta interact with a receptor at the surface of <ref>[http://www.jbc.org/content/282/28/20045.full?sid=cbf08059-44d4-4957-8ea7-0351cab9c2ac] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." ''J Biol Chem'' 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200</ref> | ||
Interferon receptor | |||
<scene name='Multiple_sclerosis/Ifnr_domains_labeled/1'>Interferon receptor domains</scene> | <scene name='Multiple_sclerosis/Ifnr_domains_labeled/1'>Interferon receptor domains</scene> | ||
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<scene name='Multiple_sclerosis/Ifnr_c_domain_labeled/1'>C-domain, with one disulfide bond</scene> | <scene name='Multiple_sclerosis/Ifnr_c_domain_labeled/1'>C-domain, with one disulfide bond</scene> | ||
<scene name='Multiple_sclerosis/Ifnr_linker_region_labeled/1'>linker region</scene> | <scene name='Multiple_sclerosis/Ifnr_linker_region_labeled/1'>linker region</scene> | ||
<scene name='Multiple_sclerosis/Ifnr_termini_labeled/1'>termini regions, no structure.</scene> | <scene name='Multiple_sclerosis/Ifnr_termini_labeled/1'>termini regions, no structure.</scene> | ||
<scene name='Multiple_sclerosis/Ifnr_clash_n-c/1'>eight clashes between domains</scene><ref name="Interferon Receptor Structure">PMID:12842042</ref> | |||
Interferon receptor bound to interferon alpha | |||
<scene name='Multiple_sclerosis/Ifna/1'>Interferon alpha</scene> | |||
__NOTOC__ | __NOTOC__ | ||
</StructureSection> | </StructureSection> | ||
=== A comparative representation of the three forms of DNA === | |||
''Sources''<ref>http://203.129.231.23/indira/nacc/</ref> | |||
{| | |||
|<applet load='IfnA.pdb' name='A' size='400' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Multiple_sclerosis/Ifna/1'/> | |||
|<applet load='IfnB.pdb' name='B' size='400' frame='true' align='right' caption='Interferon Beta' align='left' scene='Multiple_sclerosis/Interferon_beta/1'/> | |||
|} | |||
{{Clear}} | |||
<center> | |||
'''Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox''' | |||
<jmol> | |||
<jmolCheckbox> | |||
<target>A</target> | |||
<!--<scriptWhenChecked>set syncMouse ON;set syncScript OFF;sync jmolAppletB; sync > "set syncMouse | |||
ON;set syncScript OFF"</scriptWhenChecked>--> | |||
<scriptWhenChecked> sync jmolAppletB </scriptWhenChecked> | |||
<scriptWhenUnchecked> sync OFF</scriptWhenUnchecked> | |||
<text> Synchronize</text> | |||
</jmolCheckbox> | |||
</jmol> | |||
</center> | |||
== Other Treatments== | == Other Treatments== | ||
