Multiple sclerosis: Difference between revisions

Revision as of 14:48, 10 April 2012

Please have patience as I edit this page over the next few weeks! Thank you!--Kirsten Eldredge 04:22, 9 April 2012 (IDT)

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Click on the green links to the left to see key structural features of Interferon Beta (PDB entry 1ifa)

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Interferon-β

Interferon-β is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.^[1]

Interferon-β is a relatively simple biological response modifier, with several identifiable regions. It consists of five alpha helices, as well as multiple interconnecting loop regions. Helices A, B and D run parallel to one another, and helices C and E run anti-parallel to the other three helices, but parallel to one another. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.^[2]^[3]

Interferons alpha and beta interact with a receptor at the surface of ^[4]

Interferon receptor

Interferon receptor domains

N-domain, with two disulfide bonds, C-domain, with one disulfide bond linker region termini regions, no structure. eight clashes between domains^[5]

Interferon receptor bound to interferon alpha

Interferon alpha

A comparison of Interferon Alpha to Interferon Beta

Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox

↑ Voet, D., Voet, J.G., and C. Pratt. Fundamentals of Biochemistry 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.
↑ Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222
↑ https://www.uniprot.org/uniprot/P00784
↑ [1] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." J Biol Chem 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200
↑ Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure. 2003 Jul;11(7):791-802. PMID:12842042

Other Treatments

Copaxone

References

Relevant 3D Structures

Interferon Beta

1au1 - Homo sapiens

1ifa, 1wu3 - Mus musculus

Interferon Receptors

3s98, 3se3, 3se4, 1n6u, 1n6v, 2hym, 2kz1, 2lag, 3s8w, 3s9d - Homo sapiens

Proteopedia Page Contributors and Editors (what is this?)

Kirsten Eldredge

[Biochem_Text-1] Voet, D., Voet, J.G., and C. Pratt. Fundamentals of Biochemistry 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.

[Structure-2] Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222

[UniProt-3] ttps://www.uniprot.org/uniprot/P00784

[4] [1] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." J Biol Chem 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200

[Interferon_Receptor_Structure-5] Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure. 2003 Jul;11(7):791-802. PMID:12842042

[1]

[2]

[3]

[4]

[5]

@@ Line 24: / Line 24: @@
 === A comparison of Interferon Alpha to Interferon Beta ===
-{{Clear}}
-<center>
 {|
 |<applet load='1itf.pdb' name='A' size='250' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Multiple_sclerosis/Ifna_take_2/4'/>
 |<applet load='1ifa.pdb' name='B' size='250' frame='true' align='right' caption='Interferon Beta' align='left' scene='Multiple_sclerosis/Interferon_beta/7'/>
 |}
+{{Clear}}
+<center>
 '''Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox'''
@@ Line 35: / Line 36: @@
    <jmolCheckbox>
      <target>A</target>
-     <!--<scriptWhenChecked>set syncMouse ON;set syncScript OFF;sync jmolAppletB, jmolAppletA; sync > "set syncMouse
+     <!--<scriptWhenChecked>set syncMouse ON;set syncScript OFF;sync jmolAppletB; sync > "set syncMouse
 ON;set syncScript OFF"</scriptWhenChecked>-->
-              <scriptWhenChecked> sync jmolAppletB,jmolAppletA </scriptWhenChecked>
+              <scriptWhenChecked> sync jmolAppletB </scriptWhenChecked>
      <scriptWhenUnchecked> sync OFF</scriptWhenUnchecked>
       <text> Synchronize</text>

Multiple sclerosis: Difference between revisions

Revision as of 14:48, 10 April 2012

Interferon-β

A comparison of Interferon Alpha to Interferon Beta

Other Treatments

Copaxone

References

Relevant 3D Structures

Interferon Beta

Interferon Receptors

Proteopedia Page Contributors and Editors (what is this?)

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