1jk8: Difference between revisions
New page: left|200px<br /> <applet load="1jk8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jk8, resolution 2.40Å" /> '''Crystal structure o... |
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[[Image:1jk8. | [[Image:1jk8.jpg|left|200px]]<br /><applet load="1jk8" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1jk8, resolution 2.40Å" /> | caption="1jk8, resolution 2.40Å" /> | ||
'''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''<br /> | '''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''<br /> | ||
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==Disease== | ==Disease== | ||
Known diseases associated with this structure: Diabetes mellitus, rare form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], Hyperproinsulinemia, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], MODY, one form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]] | Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146880 146880]], Diabetes mellitus, rare form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], Hyperproinsulinemia, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], MODY, one form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]] | ||
==About this Structure== | ==About this Structure== | ||
1JK8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1JK8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK8 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: type 1 diabetes]] | [[Category: type 1 diabetes]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:07:48 2008'' | ||
Revision as of 14:07, 15 February 2008
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Crystal structure of a human insulin peptide-HLA-DQ8 complex
Overview
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8, and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the, major risk factors for increased susceptibility to type 1 diabetes. Using, X-ray crystallography, we have determined the three-dimensional structure, of DQ8 complexed with an immunodominant peptide from insulin. The, similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests, that diabetes is caused by the same antigen-presentation event(s) in, humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC, sequences with the DQ8 structure suggests that other structural features, of the P9 pocket in addition to position 57 contribute to susceptibility, to type 1 diabetes.
Disease
Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[146880], Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]
About this Structure
1JK8 is a Protein complex structure of sequences from Homo sapiens with NAG as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336
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