User:Marvin O'Neal/VlsE: Difference between revisions
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==Overview== | ==Overview== | ||
VlsE is a surface lipoprotein of Borrelia burgdorferi, the causative agent of [http://en.wikipedia.org/wiki/Lyme_disease Lyme Disease]. It undergoes antigenic variation ostensibly important to evasion of the host’s immune system. In addition, the protein is used for Lyme Disease diagnosis. It is composed of four similar subunits each possessing two invariable domains and one variable domain (1,2). This model represents one of these subunits with focus on the variable domain. It contains six variable regions (VRs), highlighted in green, and six invariable regions (IR1-IR6). The invariable regions are largely embedded in the protein and remain relatively unchanged within the host and across strains. IR6, a 26 amino acid long region highlighted in red and yellow, exhibits immunodominance (5, 6). The variable regions encompass 37% of the VlsE’s exposed surface area despite comprising only 25% of the protein (1, 2). However, 50% of the VR surface area is exposed while IR6, in contrast, exposes just 13.7% of its surface area. This leaves only <scene name='Studio:G5SecL01/ | VlsE is a surface lipoprotein of Borrelia burgdorferi, the causative agent of [http://en.wikipedia.org/wiki/Lyme_disease Lyme Disease]. It undergoes antigenic variation ostensibly important to evasion of the host’s immune system. In addition, the protein is used for Lyme Disease diagnosis. It is composed of four similar subunits each possessing two invariable domains and one variable domain (1,2). This model represents one of these subunits with focus on the variable domain. It contains six variable regions (VRs), highlighted in green, and six invariable regions (IR1-IR6). The invariable regions are largely embedded in the protein and remain relatively unchanged within the host and across strains. IR6, a 26 amino acid long region highlighted in red and yellow, exhibits immunodominance (5, 6). The variable regions encompass 37% of the VlsE’s exposed surface area despite comprising only 25% of the protein (1, 2). However, 50% of the VR surface area is exposed while IR6, in contrast, exposes just 13.7% of its surface area. This leaves only <scene name='Studio:G5SecL01/Ir_6_4_residues/1'>four amino residues</scene> of the antigenic IR6 unprotected; lysine-276, glutamine-279, lysine-291, and lysine-294. Thus, it is almost entirely embedded in the protein and <scene name='Studio:G5SecL01/Ir6_embedded/1'>sheilded by the variable regions </scene> (2).<br /> | ||
